Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome

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dc.contributor.authorLopez, Rene
dc.contributor.authorVial, Cecilia
dc.contributor.authorGraf, Jeronimo
dc.contributor.authorCalvo, Mario
dc.contributor.authorFerres, Marcela
dc.contributor.authorMertz, Gregory
dc.contributor.authorCuiza, Analia
dc.contributor.authorAgueero, Begonia
dc.contributor.authorAguilera, Dante
dc.contributor.authorAraya, Diego
dc.contributor.authorPailamilla, Ignacia
dc.contributor.authorParatori, Flavia
dc.contributor.authorTorres-Torres, Victor
dc.contributor.authorVial, Pablo A.
dc.contributor.authorAbarca, Juan
dc.contributor.authorMiguel Noriega, Luis
dc.contributor.authorValdivieso, Francisca
dc.contributor.authorDelgado, Iris
dc.contributor.authorMartinez, Constanza
dc.contributor.authorCarlos Chamorro, Juan
dc.contributor.authorHernandez, Jury
dc.contributor.authorPino, Marcelo
dc.contributor.authorVega, Ivonne
dc.contributor.authorOtarola, Irisol
dc.contributor.authorOrtega, Carlos
dc.contributor.authorDaube, Elizabeth
dc.contributor.authorCastillo, Constanza
dc.contributor.authorMardones, Jovita
dc.contributor.authorSanhueza, Ligia
dc.contributor.authorInostroza, Jaime
dc.contributor.authorDonoso, Solange
dc.contributor.authorNavarrete, Maritza
dc.contributor.authorAraneda, Andres
dc.contributor.authorAguilera, Teresa
dc.contributor.authorOsorio, Carola
dc.contributor.authorYobanolo, Veronica
dc.contributor.authorScholz, Luis
dc.contributor.authorRiquelme, Raul
dc.contributor.authorRiquelme, Mauricio
dc.contributor.authorMunoz, Miriam
dc.date.accessioned2025-01-23T21:11:16Z
dc.date.available2025-01-23T21:11:16Z
dc.date.issued2019
dc.description.abstractBackground: Hantavirus cardiopulmonary syndrome (HCPS) has a mortality up to 35-40% and its treatment is mainly supportive. A variable to predict progression from mild to severe disease is unavailable. This study was performed in patients with documented infection by Andes orthohantavirus, and the aim was to find a simple variable to predict progression to moderate/severe HCPS in patients with mild disease at admission. Methods: We performed a retrospective analysis of 175 patients between 2001 and 2018. Patients were categorized into mild, moderate, and severe disease according to organ failure and advanced support need at hospital admission (e.g., mechanical ventilation, vasopressors). Progression to moderate/severe disease was defined accordingly. Clinical and laboratory variables associated with progression were explored. Results: Forty patients with mild disease were identified; 14 of them progressed to moderate/severe disease. Only platelet count was different between those who progressed versus those that did not (37 (34-58) vs. 83 (64-177) K/mm(3), p < 0.001). A ROC curve analysis showed an AUC = 0.889 (0.78-1.0) p < 0.001, with a platelet count greater than 115K /mm(3) ruling out progression to moderate/severe disease. Conclusions: In patients with mild disease at presentation, platelet count could help to define priority of evacuation to tertiary care centers.
dc.fuente.origenWOS
dc.identifier.doi10.3390/v11080693
dc.identifier.eissn1999-4915
dc.identifier.urihttps://doi.org/10.3390/v11080693
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100897
dc.identifier.wosidWOS:000482993900036
dc.issue.numero8
dc.language.isoen
dc.revistaViruses-basel
dc.rightsacceso restringido
dc.subjectHantavirus cardiopulmonary syndrome
dc.subjectHantavirus pulmonary syndrome
dc.subjectthrombocytopenia
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePlatelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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