Effect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial

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dc.catalogadorgrr
dc.contributor.authorBorzutzky Schachter, Arturo José
dc.contributor.authorIturriaga Ortiz, Carolina Alejandra
dc.contributor.authorPérez Mateluna, Guillermo Andres
dc.contributor.authorCristi, Francisca
dc.contributor.authorCifuentes Aguila, Lorena Isabel
dc.contributor.authorSilva‐Valenzuela, Sergio
dc.contributor.authorVera Kellet, Cristian Andres
dc.contributor.authorCabalín Arenas, Carolina Andrea
dc.contributor.authorHoyos Bachiloglu, Rodrigo Andres
dc.contributor.authorNavarrete Dechent, Cristian Patricio
dc.contributor.authorCossio Traverso, Maria Laura
dc.contributor.authorLe Roy, Catalina
dc.contributor.authorCamargo, Jr, Carlos A.
dc.date.accessioned2024-03-19T18:42:45Z
dc.date.available2024-03-19T18:42:45Z
dc.date.issued2024
dc.description.abstractBackground: Vitamin D (VD) deficiency is common among patients with atopic dermatitis (AD) and often associated with severity. However, randomized trials of VD supplementation in AD have had equivocal results, and there is little information regarding the effect of VD supplementation on type 2 immunity in AD patients.Objectives: To investigate the efficacy of VD supplementation to decrease severity of AD and to alter type 2 immunity biomarkers.Methods: We performed a randomized, double-blind, placebo-controlled trial. We randomly assigned 101 children with AD to weekly oral vitamin D3 (VD3) or placebo for 6 weeks. The primary outcome was the change in the Severity Scoring of AD (SCORAD).Results: Mean age of subjects was 6.3 ± 4.0 years, and baseline SCORAD was 32 ± 29. At baseline, 57% of children were VD deficient, with no difference between groups. Change in 25(OH)D was significantly greater with VD3 than placebo (+43.4 ± 34.5 nmol/L vs. +2.3 ± 21.2 nmol/L, p < 0.001). SCORAD change at 6 weeks was not different between VD and placebo (-5.3 ± 11.6 vs. -5.5 ± 9.9, p = 0.91). There were no significant between-group differences in change of eosinophil counts, total IgE, Staphylococcal enterotoxin specific IgE, CCL17, CCL22, CCL27, LL-37 or Staphylococcus aureus lesional skin colonization. Vitamin D receptor (VDR) gene single nucleotide polymorphisms FokI, ApaI and TaqI did not modify subjects' response to VD supplementation.Conclusions: Among children with AD, weekly VD supplementation improved VD status but did not modify AD severity or type 2 immunity biomarkers compared to placebo (ClinicalTrials.gov NCT01996423).
dc.fechaingreso.objetodigital2024-03-19
dc.fuente.origenORCID
dc.identifier.doi10.1111/jdv.19959
dc.identifier.pubmedid38483248
dc.identifier.urihttps://doi.org/10.1111/jdv.19959
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84653
dc.information.autorucEscuela de Medicina; Borzutzky Schachter, Arturo José; 0000-0002-7904-262X; 5897
dc.information.autorucEscuela de Medicina; Iturriaga Ortiz, Carolina Alejandra; S/I; 1058623
dc.information.autorucEscuela de Medicina; Pérez Mateluna, Guillermo Andres; 0000-0001-8926-8756; 1078205
dc.information.autorucEscuela de Medicina; Cifuentes Aguila, Lorena Isabel; 0000-0002-9749-9201; 70068
dc.information.autorucEscuela de Medicina; Vera Kellet, Cristian Andres; 0000-0001-8697-9245; 9379
dc.information.autorucEscuela de Medicina; Cabalín Arenas, Carolina Andrea; 0000-0001-6344-3966; 187036
dc.information.autorucEscuela de Medicina; Hoyos Bachiloglu, Rodrigo Andres; S/I; 125227
dc.information.autorucEscuela de Medicina; Navarrete Dechent, Cristian Patricio; 0000-0003-4040-3640; 156251
dc.information.autorucEscuela de Medicina; Cossio Traverso, Maria Laura; 0000-0003-0202-3954; 16897
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaJournal of the European Academy of Dermatology and Venereology
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial
dc.typeartículo
sipa.codpersvinculados5897
sipa.codpersvinculados1058623
sipa.codpersvinculados1078205
sipa.codpersvinculados70068
sipa.codpersvinculados9379
sipa.codpersvinculados187036
sipa.codpersvinculados125227
sipa.codpersvinculados156251
sipa.codpersvinculados16897
sipa.trazabilidadORCID;2024-03-18
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