Quantification of internal dosimetry in PET patients: individualized Monte Carlo vs generic phantom-based calculations

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dc.contributor.authorNeira, Sara
dc.contributor.authorGuiu-Souto, Jacobo
dc.contributor.authorDiaz-Botana, Pablo
dc.contributor.authorPais, Paulino
dc.contributor.authorFernandez, Carlos
dc.contributor.authorPubul, Virginia
dc.contributor.authorRuibal, Alvaro
dc.contributor.authorCandela-Juan, Cristian
dc.contributor.authorGago-Arias, Araceli
dc.contributor.authorPombar, Miguel
dc.contributor.authorPardo-Montero, Juan
dc.date.accessioned2025-01-23T19:50:50Z
dc.date.available2025-01-23T19:50:50Z
dc.date.issued2020
dc.description.abstractPurpose The purpose of this work is to calculate individualized dose distributions in patients undergoing(18)F-FDG PET/CT studies through a methodology based on full Monte Carlo (MC) simulations and PET/CT patient images, and to compare such values with those obtained by employing nonindividualized phantom-based methods. Methods We developed a MC-based methodology for individualized internal dose calculations, which relies on CT images (for organ segmentation and dose deposition), PET images (for organ segmentation and distributions of activities), and a biokinetic model (which works with information provided by PET and CT images) to obtain cumulated activities. The software vGATE version 8.1. was employed to carry out the Monte Carlo calculations. We also calculated deposited doses with nonindividualized phantom-based methods (Cristy-Eckerman, Stabin, and ICRP-133). Results Median MC-calculated dose/activity values are within 0.01-0.03 mGy/MBq for most organs, with higher doses delivered especially to the bladder wall, major vessels, and brain (medians of 0.058, 0.060, 0.066 mGy/MBq, respectively). Comparison with values obtained with nonindividualized phantom-based methods has shown important differences in many cases (ranging from -80% to + 260%). These differences are significant (p < 0.05) for several organs/tissues, namely, remaining tissues, adrenals, bladder wall, bones, upper large intestine, heart, pancreas, skin, and stomach wall. Conclusions The methodology presented in this work is a viable and useful method to calculate internal dose distributions in patients undergoing medical procedures involving radiopharmaceuticals, individually, with higher accuracy than phantom-based methods, fulfilling the guidelines provided by the European Council directive 2013/59/Euratom.
dc.fuente.origenWOS
dc.identifier.doi10.1002/mp.14344
dc.identifier.eissn2473-4209
dc.identifier.issn0094-2405
dc.identifier.urihttps://doi.org/10.1002/mp.14344
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100558
dc.identifier.wosidWOS:000548159900001
dc.issue.numero9
dc.language.isoen
dc.pagina.final4588
dc.pagina.inicio4574
dc.revistaMedical physics
dc.rightsacceso restringido
dc.subjectinternal dosimetry
dc.subjectMonte Carlo
dc.subjectPET
dc.subjectremote computation
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleQuantification of internal dosimetry in PET patients: individualized Monte Carlo vs generic phantom-based calculations
dc.typeartículo
dc.volumen47
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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