Expression of kallikrein, bradykinin B2 receptor, and endothelial nitric oxide synthase in placenta in normal gestation, preeclampsia, and placenta accreta

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dc.contributor.authorCorthorn, Jenny
dc.contributor.authorGermain, Alfredo A.
dc.contributor.authorChacon, Cecilia
dc.contributor.authorRey, Sergio
dc.contributor.authorSoto, Gloria X.
dc.contributor.authorFigueroa, Carlos D.
dc.contributor.authorMueller-Esterl, Werner
dc.contributor.authorDuarte, Ignacio
dc.contributor.authorValdes, Gloria
dc.date.accessioned2025-01-21T01:06:06Z
dc.date.available2025-01-21T01:06:06Z
dc.date.issued2006
dc.description.abstractIn an effort to define the varied expression of three vasoactive markers in the clinical models of normal placenta/normal invasion (n = 11), preeclampsia/restricted trophoblast invasion (n = 15), and placenta accreta/exaggerated invasion (n = 6), we performed semiquantitative immunohistochemistry for kallikrein, bradykinin 132 receptor, and endothelial nitric oxide synthase (eNOS). In the floating villi, the syncytiotrophoblast expressed more kallikrein in placenta accreta (p < 0.05), than in normal and preeclamptic placentas, while the bradykinin B2 receptor and eNOS were similarly expressed in all groups; in the fetal endothelium, the bradykinin B2 receptor was enhanced in placenta accreta (p < 0.005), but kallikrein and eNOS were similarly expressed in the other two groups. in the extravillous trophoblast, both kallikrein and eNOS expression were higher in placenta accreta (p < 0.001), while the bradykinin B2 receptor signal was only enhanced in preeclampsia (p < 0.05). The presence and localization of kallikrein, the bradykinin B2 receptor, and eNOS in the fetomaternal interface in the three study conditions supports a local role for interrelated vasodilatory/antiaggregating systems. This first report of the variations observed in kallikrein and eNOS in a condition of exaggerated trophoblast invasion supports the participation of vasodilatation in trophoblast migration.
dc.fuente.origenWOS
dc.identifier.eissn1559-0100
dc.identifier.issn1355-008X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96089
dc.identifier.wosidWOS:000240215000016
dc.issue.numero3
dc.language.isoen
dc.pagina.final499
dc.pagina.inicio491
dc.revistaEndocrine
dc.rightsacceso restringido
dc.subjectkallikrein
dc.subjectbradykinin B2 receptor
dc.subjectendothelial nitric oxide synthase
dc.subjectnormal placenta
dc.subjectpreeclampsia
dc.subjectaccreta
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleExpression of kallikrein, bradykinin B2 receptor, and endothelial nitric oxide synthase in placenta in normal gestation, preeclampsia, and placenta accreta
dc.typeartículo
dc.volumen29
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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