Clinical features and prognosis of malignant small bowel tumors: Experience from a university hospital in Chile

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dc.contributor.authorSilva, Felipe
dc.contributor.authorBustamante, Miguel
dc.contributor.authorLatorre, Gonzalo
dc.contributor.authorFlandez, Jorge
dc.contributor.authorMontero, Isabella
dc.contributor.authorDukes, Eitan
dc.contributor.authorGandara, Vicente
dc.contributor.authorRobles, Camila
dc.contributor.authorUribe, Javier
dc.contributor.authorIglesias, Andres
dc.contributor.authorBellolio, Felipe
dc.contributor.authorMolina, Maria Elena
dc.contributor.authorMigueles, Rodrigo
dc.contributor.authorUrrejola, Gonzalo
dc.contributor.authorLarach, Tomas
dc.contributor.authorBesser, Nicolas
dc.contributor.authorSharp, Allan
dc.contributor.authorAguero, Carlos
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorVargas, Jose Ignacio
dc.contributor.authorCandia, Roberto
dc.contributor.authorMonrroy, Hugo
dc.contributor.authorDe Simone, Federico
dc.contributor.authorEspino, Alberto
dc.date.accessioned2025-01-20T16:17:14Z
dc.date.available2025-01-20T16:17:14Z
dc.date.issued2024
dc.description.abstractBackground: Small bowel tumors (SBT) are infrequent and represent a small proportion of digestive neoplasms. There is scarce information about SBT in Latin America. Aim: To describe the epidemiology, clinical characteristics, diagnostic methods, and survival of malignant SBTs. Methods: Retrospective observational study of adult patients with histopathological diagnosis of SBT between 2007 and 2021 in a university hospital in Chile. Results: A total of 104 patients [51.9% men; mean age 57 years] with SBT. Histological type: neuroendocrine tumor (NET) (43.7%, n = 38), gastrointestinal stromal tumors (GIST) (21.8%, n = 19), lymphoma (17.2%, n = 15) and adenocarcinoma (AC) (11.5%, n = 10). GIST was more frequent in duodenum (50%; n = 12) and NET in the ileum (65.8%; n = 25). Metastasis was observed in 17 cases, most commonly from colon and melanoma. Nausea and vomiting were significantly more often observed in AC ( p = 0.035), as well as gastrointestinal bleeding in GIST ( p = 0.007). The most common diagnostic tools were CT and CT enteroclysis with an elevated diagnostic yield (86% and 94% respectively). The 5 -year survival of GIST, NET, lymphoma and AC were 94.7% (95%CI: 68.1 - 99.2), 82.2% (95%CI: 57.6 - 93.3), 40.0% (95%CI: 16.5 - 82.8) and 25.9% (95%CI: 4.5 - 55.7%), respectively. NET (HR 6.1; 95%CI: 2.1 - 17.2) and GIST (HR 24.4; 95%CI: 3.0 - 19.8) were independently associated with higher survival compared to AC, adjusted for age and sex. Conclusions: Malignant SBT are rare conditions and NETs are the most common histological subtype. Clinical presentation at diagnosis, location or complications may suggest a more probable diagnosis. GIST and NET are associated with better survival compared to other malignant subtypes. (c) 2024 Elsevier Espana, S.L.U. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.gastrohep.2024.01.013
dc.identifier.issn0210-5705
dc.identifier.urihttps://doi.org/10.1016/j.gastrohep.2024.01.013
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90587
dc.identifier.wosidWOS:001236422600001
dc.issue.numero5
dc.language.isoen
dc.pagina.final499
dc.pagina.inicio491
dc.revistaGastroenterologia y hepatologia
dc.rightsacceso restringido
dc.subjectSmall bowel adenocarcinoma
dc.subjectNeuroendocrine tumors
dc.subjectGastrointestinal stromal tumors
dc.subjectEnteroclysis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical features and prognosis of malignant small bowel tumors: Experience from a university hospital in Chile
dc.typeartículo
dc.volumen47
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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