Oral polio vaccine in infants does not interfere in detection of enterovirus in blood

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dc.contributor.authorGonzalez, Marcela
dc.contributor.authorSandoval, Carmen
dc.contributor.authorValenzuela, Patricia
dc.contributor.authorMontecinos, Luisa
dc.contributor.authorMartinez, Constanza
dc.contributor.authorGodoy, Paula
dc.contributor.authorAbarca, Katia
dc.date.accessioned2024-01-10T13:51:37Z
dc.date.available2024-01-10T13:51:37Z
dc.date.issued2013
dc.description.abstractIntroduction: There is not known if a viraemia post-oral polio vaccine (OPV) is detectable by modern molecular techniques. Such viraemia could affect the performance of the real time-polymerase chain reaction (PCR) for non polio enterovirus (EV) detection, technique of growing clinical use for the study of febrile infants. Objective: To determine viraemia post-first dose of OPV in healthy infants, by molecular techniques. Patients and Methods: 50 infants less than three months without previous VPO were randomized in 5 groups: a control group with prevaccination blood sample (BS), group 1 BS at day 2, group 2 BS at day 4, group 3, BS at day 6 and group 4, BS at day 8 post-vaccination. Conventional and specific PCR for poliovirus and real time PCR for non polio EV were performed in BS and in OPV samples. Results: No genetic material of poliovirus was detected in any infant, while in 9 of them (18%) non polio EV was identified. Real time PCR for EV did not amplify poliovirus from OPV samples. Discussion: Results suggest that no post VPO viraemia detectable by molecular methods exists. Considering that real time PCR for EV does not allow to identify polio virus, no false positives of the test are expected as a result of a recent VPO vaccination. We documented presence of non polio EV in blood of healthy asymptomatic infants.
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0716-10182013000600009
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.pubmedidMEDLINE:24522306
dc.identifier.urihttps://doi.org/10.4067/S0716-10182013000600009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79614
dc.identifier.wosidWOS:000329082600009
dc.information.autorucMedicina;Abarca K;S/I;70281
dc.information.autorucMedicina;Godoy P;S/I;113511
dc.information.autorucMedicina;Martinez C;S/I;1008613
dc.information.autorucMedicina;Montecinos L;S/I;117268
dc.information.autorucMedicina;Sandoval C;S/I;167314
dc.information.autorucMedicina;Valenzuela P;S/I;60674
dc.issue.numero6
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final629
dc.pagina.inicio626
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsregistro bibliográfico
dc.subjectPoliovirus vaccine viraemia
dc.subjectenterovirus
dc.subjectPCR
dc.subjectreal time PCR
dc.subjectCOMMON VIRAL-INFECTIONS
dc.subjectLABORATORY DIAGNOSIS
dc.subjectPCR
dc.subjectVIREMIA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOral polio vaccine in infants does not interfere in detection of enterovirus in blood
dc.typeartículo
dc.volumen30
sipa.codpersvinculados70281
sipa.codpersvinculados113511
sipa.codpersvinculados1008613
sipa.codpersvinculados117268
sipa.codpersvinculados167314
sipa.codpersvinculados60674
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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