Race and sex differences in HDL peroxide content among American adults with and without type 2 diabetes

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dc.article.number18
dc.contributor.authorFlaherty, Shelby M.
dc.contributor.authorWood, Elizabeth K.
dc.contributor.authorRyff, Carol D.
dc.contributor.authorLove, Gayle D.
dc.contributor.authorKelesidis, Theodoros
dc.contributor.authorBerkowitz Fiebich, Loni
dc.contributor.authorEcheverría Errázuriz, Guadalupe
dc.contributor.authorRivera Vega, Katherine Solange
dc.contributor.authorRigotti Rivera, Attilio
dc.contributor.authorCoe, Christopher L.
dc.date.accessioned2022-03-21T19:06:40Z
dc.date.available2022-03-21T19:06:40Z
dc.date.issued2022
dc.date.updated2022-02-13T01:03:09Z
dc.description.abstractBackground: High-density lipoprotein (HDL) plays a critical role in protection against atherosclerosic and cardiovascular disease (ASCVD). In addition to contributing to clearing excess vascular cholesterol, HDL particles exhibit antioxidative functions, helping to attenuate adverse effects of oxidized low-density lipoproteins. However, these beneficial properties can be undermined by oxidative stress, inflammation, and unhealthy lifestyles and diet, as well as influenced by race and sex. Thus, when assessing cardiovascular risk, it is important to consider multifactorial aspects of HDL, including antioxidant activity rather than just total amount and type of HDL-cholesterol (HDL-C) particles. Because prior research showed HDL peroxide content (HDLperox) can be inversely associated with normal anti-oxidant HDL activity, elevated HDLperox may serve as a bioindicator of HDL dysfunction. Methods: In this study, data from a large national cohort of Americans was utilized to determine the impact of sex, race, and diabetes status on HDLperox in middle-aged and older adults. A previously developed cell-free fluorometric method was utilized to quantify HDLperox in serum depleted of apo-B containing lipoproteins. Results: In keeping with predictions, white men and diabetics exhibited HDLperox in the atypical upper range, suggestive of less functional HDL. White men had higher HDLperox levels than African American males (13.46 ± 6.10 vs. 10.88 ± 5.81, p < .001). There was also a significant main effect of type 2 diabetes (F(1,1901) = 14.9, p < .0001). Overall, African Americans evinced lower HDLperox levels, despite more obesity (10.3 ± 4.7 vs.11.81 ± 5.66 for Whites) suggesting that other aspects of lipid metabolism and psychosocial factors account for the higher prevalence of ASCVD in African Americans. Conclusion: This research helps to provide a more comprehensive understanding of HDL function in a racially and metabolically diverse adult population. HDLperox content was significantly different in adults with type 2 diabetes, and distinctive in nondiabetic White males, and suggests other processes account for the higher prevalence of ASCVD among African Americans.
dc.format.extent12 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationLipids in Health and Disease. 2022 Feb 06;21(1):18
dc.identifier.doi10.1186/s12944-021-01608-4
dc.identifier.urihttps://doi.org/10.1186/s12944-021-01608-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/63599
dc.information.autorucEscuela de Medicina ; Berkowitz Fiebich, Loni ; 0000-0002-8562-4845 ; 172010
dc.information.autorucEscuela de Medicina ; Echeverría Errázuriz, Guadalupe ; 0000-0002-2915-0171 ; 9504
dc.information.autorucEscuela de Medicina ; Rivera Vega, Katherine Solange ; 0000-0003-1850-5560 ; 1063705
dc.information.autorucEscuela de Medicina ; Rigotti Rivera, Attilio ; 0000-0002-0495-3525 ; 68489
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.revistaLipids in Health and Disease
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectCholesteroles_ES
dc.subjectDyslipidemia lipid peroxidationes_ES
dc.subjectObesityes_ES
dc.subjectHDL functiones_ES
dc.subjectDiabeteses_ES
dc.subjectRacees_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRace and sex differences in HDL peroxide content among American adults with and without type 2 diabeteses_ES
dc.typeartículo
dc.volumen21
sipa.codpersvinculados172010
sipa.codpersvinculados9504
sipa.codpersvinculados1063705
sipa.codpersvinculados68489
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