Influence of particle size on the in vitro digestibility of protein-coated lipid nanoparticles

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dc.contributor.authorTroncoso, Elizabeth
dc.contributor.authorMiguel Aguilera, Jose
dc.contributor.authorMcClements, David Julian
dc.date.accessioned2024-01-10T12:06:03Z
dc.date.available2024-01-10T12:06:03Z
dc.date.issued2012
dc.description.abstractThe influence of particle size on the in vitro digestion of beta-lactoglobulin (BLG)-coated lipid nanoparticles was examined using simulated small intestine conditions. Nanoemulsions were prepared by high-pressure homogenization and organic solvent (hexane) evaporation. The effect of the initial organic phase composition on the size, microstructure, electrical properties, and digestion of the lipid nanoparticles was evaluated. The radius of the nanoparticles decreased (from 85 to 48 nm) as the solvent concentration in the initial organic phase increased (from 0% to 95%). The lipid digestion rate initially decreased with decreasing particle radius (for r = 85-59 nm), but then it increased (for r = 59-48 nm). This dependence is contrary to the usual assumption that lipid digestion increases with increasing lipid surface area. Our results suggest that the structure of the protein layer coating the lipid nanoparticles has an important effect on lipid digestion. (C) 2012 Elsevier Inc. All rights reserved.
dc.description.funderNational Institute of Food and Agriculture
dc.description.funderUS Department of Agriculture
dc.description.funderMassachusetts Agricultural Experiment Station, the Department of Food Science
dc.description.funderFondecyt
dc.description.funderCONICYT (Chile)
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jcis.2012.05.054
dc.identifier.eissn1095-7103
dc.identifier.issn0021-9797
dc.identifier.pubmedidMEDLINE:22742991
dc.identifier.urihttps://doi.org/10.1016/j.jcis.2012.05.054
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76108
dc.identifier.wosidWOS:000307027600016
dc.information.autorucIngeniería;Aguilera J;S/I;99054
dc.information.autorucIngeniería;Troncoso E ;S/I;174028
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final116
dc.pagina.inicio110
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaJOURNAL OF COLLOID AND INTERFACE SCIENCE
dc.rightsacceso restringido
dc.subjectNanoemulsions
dc.subjectEmulsions
dc.subjectLipid nanoparticles
dc.subjectbeta-Lactoglobulin
dc.subjectDigestion
dc.subjectDelivery
dc.subjectBETA-CAROTENE NANODISPERSIONS
dc.subjectPHYSICAL-PROPERTIES
dc.subjectNANO-EMULSIONS
dc.subjectSTABILITY
dc.subjectLIPASE
dc.subjectOIL
dc.subjectPH
dc.subjectBIOAVAILABILITY
dc.subjectIMPACT
dc.subjectLACTOGLOBULIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInfluence of particle size on the in vitro digestibility of protein-coated lipid nanoparticles
dc.typeartículo
dc.volumen382
sipa.codpersvinculados99054
sipa.codpersvinculados174028
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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