Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly

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dc.contributor.authorDanpanichkul, Pojsakorn
dc.contributor.authorSuparan, Kanokphong
dc.contributor.authorNg, Cheng Han
dc.contributor.authorDejvajara, Disatorn
dc.contributor.authorKongarin, Siwanart
dc.contributor.authorPanpradist, Nuttada
dc.contributor.authorChaiyakunapruk, Nathorn
dc.contributor.authorMuthiah, Mark D.
dc.contributor.authorChen, Vincent L.
dc.contributor.authorHuang, Daniel Q.
dc.contributor.authorDiaz, Luis Antonio
dc.contributor.authorNoureddin, Mazen
dc.contributor.authorArab, Juan Pablo
dc.contributor.authorWijarnpreecha, Karn
dc.date.accessioned2025-01-20T17:05:30Z
dc.date.available2025-01-20T17:05:30Z
dc.date.issued2024
dc.description.abstractBackground & Aims: Alcohol -associated liver diseases (ALDs) and alcohol use disorder (AUD) pose a global health risk. AUD is underrecognized in the elderly, and the burden of AUD complications, including ALD, may increase with aging populations and rising alcohol intake. However, there is a lack of epidemiological evidence on AUD and ALD in the elderly. Methods: Using the Global Burden of Disease Study 2019, we analyzed the prevalence, mortality, disability -adjusted life years (DALYs), age -standardized rates (ASRs), and temporal change from 2000 to 2019 of ALD and AUD in the overall population and the elderly (65-89 years). The findings were categorized by sex, region, nation, and sociodemographic index. Results: The prevalence rates of ALD in the elderly were higher than those in adolescents and young adults, whereas AUD levels were lower than those in adolescents and young adults. In 2019, there were 9.39 million cases (8.69% of cases in the overall population) of AUD, 3.23 million cases (21.8% of cases in the overall population) of alcohol -associated cirrhosis, and 68,468 cases (51.27% of cases in the overall population) of liver cancer from alcohol among the elderly. ASRs of the prevalence of ALD and AUD in the elderly increased in most regions; on the contrary, ASRs of death and DALYs decreased in most regions. Nevertheless, ASRs of death and DALYs from liver cancer from alcohol increased in many areas. Conclusions: Our findings highlighted the increased prevalence of ALD in the elderly, with a burden of AUD comparable with that in the overall population. Public health strategies on ALD and AUD targeting the elderly are urgently needed. Impact and implications: The burden of alcohol -associated liver disease (ALD) and alcohol use disorder (AUD) is increasing. Advances in healthcare and education have resulted in a remarkable spike in life expectancy and a consequential population aging. Nevertheless, little is known about the epidemiology of ALD and AUD in the elderly. Our study indicates the increasing burden of ALD and AUD in the elderly population, necessitating early detection, intervention, and tailored care to the unique needs and complexities faced by older individuals grappling with these conditions. (c) 2024 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.description.funderChilean government through the Fondo Nacional de Desarrollo Cientifico y Tecnologico
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jhepr.2024.101020
dc.identifier.eissn2589-5559
dc.identifier.urihttps://doi.org/10.1016/j.jhepr.2024.101020
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90716
dc.identifier.wosidWOS:001208863600001
dc.issue.numero4
dc.language.isoen
dc.revistaJhep reports
dc.rightsacceso restringido
dc.subjectAlcohol-associated cirrhosis
dc.subjectPublic health
dc.subjectGeriatric
dc.subjectEpidemiology
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGlobal and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly
dc.typeartículo
dc.volumen6
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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