Evaluation of the effect of intravenous lidocaine on propofol requirements during total intravenous anaesthesia as measured by bispectral index(dagger)

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dc.contributor.authorAltermatt, F. R.
dc.contributor.authorBugedo, D. A.
dc.contributor.authorDelfino, A. E.
dc.contributor.authorSolari, S.
dc.contributor.authorGuerra, I.
dc.contributor.authorMunoz, H. R.
dc.contributor.authorCortinez, L. I.
dc.date.accessioned2024-01-10T12:38:48Z
dc.date.available2024-01-10T12:38:48Z
dc.date.issued2012
dc.description.abstractI.V. lidocaine is increasingly used as an adjuvant during general anaesthesia. The aim of this study was to evaluate the effect of i.v. lidocaine in reducing propofol anaesthetic requirements during total i.v. anaesthesia (TIVA) maintenance and to evaluate its effect on early recovery from anaesthesia.
dc.description.abstractForty adult patients undergoing elective laparoscopic cholecystectomy under TIVA were randomly allocated into the lidocaine group (administered 1.5 mg kg(1) i.v. lidocaine over 5 min followed by 2 mg kg(1) h(1)) and the control group (administered an equal volume of saline). Propofol was administered using a target-controlled infusion to maintain the bispectral index values between 40 and 60. After surgery, all infusions were discontinued and the time to extubation was recorded. Serial arterial blood samples were drawn to assess drug plasma levels.
dc.description.abstractThe maintenance dose of propofol was significantly lower in the lidocaine group [6.00 (0.97) mg kg(1) h(1)] vs the control group [7.25 (1.13) mg kg(1) h(1); P0.01]. Propofol plasma levels measured at the end of the infusion were 3.71 (0.89) g ml(1) in the lidocaine group and 3.67 (1.28) g ml(1) in the control group (P0.91). The median time to extubation was longer (11.0 min; range: 10.021.0) in the lidocaine group vs the control group (8.3 min; range: 5.512.5; P0.02).
dc.description.abstractI.V. lidocaine reduces propofol requirements during the maintenance phase of TIVA, particularly during surgical stimulation. This sparing effect is associated with an increased time to extubation. Owing to its effect on early recovery from anaesthesia, i.v. lidocaine should be taken into account when used as a component of i.v. anaesthesia.
dc.description.funderDepartmento de Anestesiologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile
dc.fechaingreso.objetodigital2024-05-07
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1093/bja/aes097
dc.identifier.issn0007-0912
dc.identifier.pubmedidMEDLINE:22490315
dc.identifier.urihttps://doi.org/10.1093/bja/aes097
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77100
dc.identifier.wosidWOS:000304199500013
dc.information.autorucMedicina;Altermatt F;S/I;7381
dc.information.autorucMedicina;Cortinez L;S/I;79356
dc.information.autorucMedicina;Delfino A;S/I;129220
dc.information.autorucMedicina;Guerra I ;S/I;117495
dc.information.autorucMedicina;Munoz H;S/I;73573
dc.information.autorucMedicina;Solari S ;S/I;1871
dc.issue.numero6
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final983
dc.pagina.inicio979
dc.publisherOXFORD UNIV PRESS
dc.revistaBRITISH JOURNAL OF ANAESTHESIA
dc.rightsregistro bibliográfico
dc.subjectbispectral index
dc.subjectlidocaine
dc.subjectpropofol
dc.subjectTIVA
dc.subjectMETABOLITES
dc.subjectLIGNOCAINE
dc.subjectINDEX
dc.titleEvaluation of the effect of intravenous lidocaine on propofol requirements during total intravenous anaesthesia as measured by bispectral index(dagger)
dc.typeartículo
dc.volumen108
sipa.codpersvinculados7381
sipa.codpersvinculados79356
sipa.codpersvinculados129220
sipa.codpersvinculados117495
sipa.codpersvinculados73573
sipa.codpersvinculados1871
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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