Pathophysiological role of metabolic flexibility on metabolic health

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dc.catalogadorvdr
dc.contributor.authorGalgani Fuentes, José
dc.contributor.authorFernandez-Verdejo, Rodrigo
dc.date.accessioned2024-10-16T15:11:41Z
dc.date.available2024-10-16T15:11:41Z
dc.date.issued2020
dc.description.abstractGlucose, fatty acids, and amino acids among others are oxidized to generate adenosine triphosphate (ATP). These fuels are supplied from the environment (through food intake) and internal depots (through lipolysis, glycogenolysis, and proteolysis) at different rates throughout the day. Complex adaptive systems permit to accommodate fuel oxidation according to fuel availability. This capacity of a cell, tissue, or organism to adapt fuel oxidation to fuel availability is defined as metabolic flexibility (MetF). There are conditions, such as insulin resistance, diabetes, and obesity, in which MetF seems to be impaired. The observation that those conditions are accompanied by mitochondrial dysfunction has set the basis to propose a link between mitochondrial dysfunction, metabolic inflexibility, and metabolic health. We here highlight the evidence about the notion that MetF influences metabolic health.
dc.fechaingreso.objetodigital2024-10-16
dc.format.extent14 páginas
dc.fuente.origenConveris
dc.fuente.origenORCID;2024-10-14
dc.identifier.doi10.1111/obr.13131
dc.identifier.issn1467-7881
dc.identifier.scopusid2-s2.0-85089698796
dc.identifier.urihttps://doi.org/10.1111/obr.13131
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88260
dc.information.autorucEscuela de Medicina; Galgani Fuentes, José; 0000-0001-9793-8561; 1011272
dc.information.autorucDepartamento de Ciencias de la Salud; Fernandez-Verdejo, Rodrigo; 0000-0002-5948-2281; 1071485
dc.issue.numero2
dc.language.isoes
dc.nota.accesocontenido completo
dc.revistaObesity Reviews
dc.rightsacceso restringido
dc.subjectInsulin resistance
dc.subjectInsulin sensitivity
dc.subjectLipotoxicity
dc.subjectObesity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePathophysiological role of metabolic flexibility on metabolic health
dc.typeartículo de revisión
dc.volumen22
sipa.codpersvinculados1011272
sipa.codpersvinculados1071485
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2024-10-14
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