Laminar segregation of GABAergic neurons in the avian nucleus isthmi pars magnocellularis: A retrograde tracer and comparative study

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dc.contributor.authorFaunes, Macarena
dc.contributor.authorFernandez, Sara
dc.contributor.authorGutierrez Ibanez, Cristian
dc.contributor.authorIwaniuk, Andrew N.
dc.contributor.authorWylie, Douglas R.
dc.contributor.authorMpodozis, Jorge
dc.contributor.authorKarten, Harvey J.
dc.contributor.authorMarin, Gonzalo
dc.date.accessioned2024-01-10T13:14:16Z
dc.date.available2024-01-10T13:14:16Z
dc.date.issued2013
dc.description.abstractThe isthmic complex is part of a visual midbrain circuit thought to be involved in stimulus selection and spatial attention. In birds, this circuit is composed of the nuclei isthmi pars magnocellularis (Imc), pars parvocellularis (Ipc), and pars semilunaris (SLu), all of them reciprocally connected to the ipsilateral optic tectum (TeO). The Imc conveys heterotopic inhibition to the TeO, Ipc, and SLu via widespread -aminobutyric acid (GABA)ergic axons that allow global competitive interactions among simultaneous sensory inputs. Anatomical studies in the chick have described a cytoarchitectonically uniform Imc nucleus containing two intermingled cell types: one projecting to the Ipc and SLu and the other to the TeO. Here we report that in passerine species, the Imc is segregated into an internal division displaying larger, sparsely distributed cells, and an external division displaying smaller, more densely packed cells. In vivo and in vitro injections of neural tracers in the TeO and the Ipc of the zebra finch demonstrated that neurons from the external and internal subdivisions project to the Ipc and the TeO, respectively, indicating that each Imc subdivision contains one of the two cell types hodologically defined in the chick. In an extensive survey across avian orders, we found that, in addition to passerines, only species of Piciformes and Rallidae exhibited a segregated Imc, whereas all other groups exhibited a uniform Imc. These results offer a comparative basis to investigate the functional role played by each Imc neural type in the competitive interactions mediated by this nucleus. J. Comp. Neurol. 521:17271742, 2013. (c) 2012 Wiley Periodicals, Inc.
dc.description.funderChilean National Science and Technology Research Fund (FONDECYT)
dc.description.funderNatural Sciences and Engineering Research Council (NSERC)
dc.fechaingreso.objetodigital04-04-2024
dc.format.extent16 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/cne.23253
dc.identifier.eissn1096-9861
dc.identifier.issn0021-9967
dc.identifier.pubmedidMEDLINE:23124899
dc.identifier.urihttps://doi.org/10.1002/cne.23253
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78389
dc.identifier.wosidWOS:000317286500003
dc.information.autorucMedicina;Faunes M;S/I;65736
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1742
dc.pagina.inicio1727
dc.publisherWILEY
dc.revistaJOURNAL OF COMPARATIVE NEUROLOGY
dc.rightsacceso restringido
dc.subjectnucleus isthmi
dc.subjectoptic tectum
dc.subjectstimulus selection
dc.subjectGABAergic
dc.subjecthodological homology
dc.subjectparcellation
dc.subjectCOMPETITIVE STIMULUS SELECTION
dc.subjectHIGHER-LEVEL PHYLOGENY
dc.subjectOPTIC TECTUM
dc.subjectIMMUNOREACTIVITY
dc.subjectINHIBITION
dc.subjectMIDBRAIN
dc.subjectGALLUS
dc.subjectPARVOCELLULARIS
dc.subjectPATHWAY
dc.subjectSIGNALS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLaminar segregation of GABAergic neurons in the avian nucleus isthmi pars magnocellularis: A retrograde tracer and comparative study
dc.typeartículo
dc.volumen521
sipa.codpersvinculados65736
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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