GW1229, a novel neuropeptide Y Y-1 receptor antagonist, inhibits the vasoconstrictor effect of neuropeptide Y in the hamster microcirculation

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dc.contributor.authorBitran, M
dc.contributor.authorDaniels, AJ
dc.contributor.authorBoric, MP
dc.date.accessioned2025-01-21T01:33:34Z
dc.date.available2025-01-21T01:33:34Z
dc.date.issued1997
dc.description.abstractWe studied the effect of GW1229, a novel neuropeptide Y Y-1 receptor antagonist, on the vasoconstriction induced by neuropeptide Y and structurally related analogs in the hamster cheek pouch microcirculation. Changes in arteriolar diameter and microvascular conductance were assessed by intravital microscopy and measurement of sodium(22) clearance. GW1229 did not affect basal vascular conductance but inhibited, concentration dependently, the reduction in arteriolar diameter and vascular conductance induced by 100 nM neuropeptide Y. GW1229 also counteracted the vasoconstrictor effect of 100 nM [Leu(31),Pro(34)]neuropeptide Y, and that of 300 nM neuropeptide Y-(13-36). In contrast, GW1229 had no effect on the vasoconstriction induced by noradrenaline. We conclude that the vasoconstrictor effect of neuropeptide Y in the hamster cheek pouch is mediated by neuropeptide Y Y-1 receptors. The maintenance of physiological tone in this vascular bed does not involve the participation of endogenous neuropeptide Y.
dc.fuente.origenWOS
dc.identifier.issn0014-2999
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97438
dc.identifier.wosidWOS:A1997WE79500007
dc.issue.numero1
dc.language.isoen
dc.pagina.final47
dc.pagina.inicio43
dc.revistaEuropean journal of pharmacology
dc.rightsacceso restringido
dc.subjectneuropeptide Y receptor antagonist
dc.subjectGW1229
dc.subjectneuropeptide Y Y-1 receptor
dc.subjectmicrocirculation hamster
dc.subject.ods03 Good Health and Well-being
dc.subject.ods02 Zero Hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleGW1229, a novel neuropeptide Y Y-1 receptor antagonist, inhibits the vasoconstrictor effect of neuropeptide Y in the hamster microcirculation
dc.typeartículo
dc.volumen319
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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