The presence of the HLA-DRB1 shared epitope correlates with erosive disease in Chilean patients with rheumatoid arthritis

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dc.contributor.authorMassardo, L
dc.contributor.authorGareca, N
dc.contributor.authorCartes, MA
dc.contributor.authorCervilla, V
dc.contributor.authorGonzalez, A
dc.contributor.authorJacobelli, S
dc.date.accessioned2024-01-10T14:22:05Z
dc.date.available2024-01-10T14:22:05Z
dc.date.issued2002
dc.description.abstractObjective. To assess the contribution of the HLA-DRB1 shared epitope (SE) to the radiological outcome of rheumatoid arthritis (RA) after 6 yr of follow-up in a reported series of 129 Chilean patients with established disease.
dc.description.abstractMethods. A prospective study was conducted between 1992 and 1998 using hand radiographs to assess disease outcome in a published series of patients in whom two doses of the SE were present in 20%, one dose was present in 34% and the SE was absent in 46%. At study entry, 29 of the 92 patients with hand radiographs were at Steinbrocker stages I or II (non-erosive), with a median disease duration of 2.8 yr (0.4-17).
dc.description.abstractResults. In 1998, 113 (87%) of the patients were alive. One hundred and eight patients underwent complete clinical evaluation. Their median age was 57 yr (range 30-81) and the median disease duration was 15 yr (6-50). We were able to study 25 of the 29 patients who had non-erosive disease at study entry in 1992. We found that 10 of 11 patients having one or two doses of the SE developed erosive disease compared with three of 14 without the SE (Yates' corrected P=0.0023, relative risk 4.24, 95% confidence interval 1.53-11.77).
dc.description.abstractConclusions. These observations support and extend the notion that the presence of the SE in one or two doses can predict the development of erosions even in RA populations in whom the SE is not as prevalent as in Caucasians.
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1093/rheumatology/41.2.153
dc.identifier.issn1462-0324
dc.identifier.pubmedidMEDLINE:11886963
dc.identifier.urihttps://doi.org/10.1093/rheumatology/41.2.153
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79858
dc.identifier.wosidWOS:000174398100008
dc.information.autorucMedicina;Iacobelli S;S/I;98345
dc.information.autorucMedicina;Massardo M;S/I;100068
dc.issue.numero2
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final156
dc.pagina.inicio153
dc.publisherOXFORD UNIV PRESS
dc.revistaRHEUMATOLOGY
dc.rightsregistro bibliográfico
dc.subjectshared epitope
dc.subjectradiological progression
dc.subjecterosive disease
dc.subjectrheumatoid arthritis
dc.subjectCLINICAL EXPRESSION
dc.subjectSUSCEPTIBILITY
dc.subjectASSOCIATION
dc.subjectSEVERITY
dc.subjectALLELES
dc.subjectGENES
dc.subjectGENOTYPE
dc.subjectLOCUS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe presence of the HLA-DRB1 shared epitope correlates with erosive disease in Chilean patients with rheumatoid arthritis
dc.typeartículo
dc.volumen41
sipa.codpersvinculados98345
sipa.codpersvinculados100068
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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