An inverse fitting strategy to determine the constrained mixture model parameters: application in patient-specific aorta

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dc.contributor.authorNavarrete, Alvaro
dc.contributor.authorUtrera, Andres
dc.contributor.authorRivera, Eugenio
dc.contributor.authorLatorre, Marcos
dc.contributor.authorCelentano, Diego J.
dc.contributor.authorGarcia-Herrera, Claudio M.
dc.date.accessioned2025-01-20T17:22:32Z
dc.date.available2025-01-20T17:22:32Z
dc.date.issued2023
dc.description.abstractThe Constrained Mixture Model (CMM) is a novel approach to describe arterial wall mechanics, whose formulation is based on a referential physiological state. The CMM considers the arterial wall as a mixture of load-bearing constituents, each of them with characteristic mass fraction, material properties, and deposition stretch levels from its stress-free state to the in-vivo configuration. Although some reports of this model successfully assess its capabilities, they barely explore experimental approaches to model patient-specific scenarios. In this sense, we propose an iterative fitting procedure of numerical-experimental nature to determine material parameters and deposition stretch values. To this end, the model has been implemented in a finite element framework, and it is calibrated using reported experimental data of descending thoracic aorta. The main results obtained from the proposed procedure consist of a set of material parameters for each constituent. Moreover, a relationship between deposition stretches and residual strain measurements (opening angle and axial stretch) has been numerically proved, establishing a strong consistency between the model and experimental data.
dc.description.funderAgencia Nacional de Investigacin y Desarrollo10.13039/501100020884
dc.fuente.origenWOS
dc.identifier.doi10.3389/fbioe.2023.1301988
dc.identifier.issn2296-4185
dc.identifier.urihttps://doi.org/10.3389/fbioe.2023.1301988
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91484
dc.identifier.wosidWOS:001112622900001
dc.language.isoen
dc.revistaFrontiers in bioengineering and biotechnology
dc.rightsacceso restringido
dc.subjectconstrained mixture
dc.subjectarterial wall
dc.subjectdeposition stretch
dc.subjectmaterial parameters
dc.subjectfinite element method
dc.titleAn inverse fitting strategy to determine the constrained mixture model parameters: application in patient-specific aorta
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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