Prevention of renal ischemic reperfusion injury using FTY 720 and ICAM-1 antisense oligonucleotides

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dc.contributor.authorOrtiz, AM
dc.contributor.authorTroncoso, P
dc.contributor.authorKahan, BD
dc.date.accessioned2024-01-10T12:41:45Z
dc.date.available2024-01-10T12:41:45Z
dc.date.issued2003
dc.description.abstractBackground. Renal damage secondary to ischemia-reperfusion injuries (I-R) is frequent in organ transplantation and adversely affects the graft survival. An important component of this damage is caused by initial adhesion of neutrophils and lymphocytes to endothelial cells. FTY 720, which induces lymphopenia, has previously been shown to display protective effects in models of I-R. The purpose of the present study was to evaluate the combination of FTY 720 and intracellular adhesion molecule and ICAM-1 antisense oligonucleotides (AS-oligos), an agent designed to block the adhesion process.
dc.description.abstractMethods. Sprague-Dawley rats underwent syngenic kidney transplantation after donor kidneys had been preserved in cold solution for 2 hours. The treatment groups included: (1) FTY 720 (1 mg/kg) before reperfusion, (2) AS-oligos (2 mg/kg) during kidney perfusion, and (3) the combination of FTY 720 and AS-oligos. All animals were followed daily after transplantation; some were sacrificed on the second day for histologic analysis.
dc.description.abstractResults. All treated groups showed a maximal serum creatinine that was significantly less than the control (group 1: 2.76 +/- 1.4, group 2: 2.44 +/- 2.05, group 3: 1.51 +/- 0.42, and control: 4.04 +/- 0.5; P < .01) and returned to the basal value earlier. Also, treated animals showed less histologic stigmata of acute tubular damage. FTY 720 and AS-oligos used in combination showed a mild additive effect.
dc.description.abstractConclusions. The use of FTY 720 and/or AS-oligo's significantly prevents functional renal damage secondary to I-R, displaying a mild additive effect in this model. Both agents offer the advantage of use during the donor and the graft operations.
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0041-1345(03)00374-9
dc.identifier.eissn1873-2623
dc.identifier.issn0041-1345
dc.identifier.pubmedidMEDLINE:12826223
dc.identifier.urihttps://doi.org/10.1016/S0041-1345(03)00374-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77447
dc.identifier.wosidWOS:000183852600090
dc.information.autorucMedicina;Ortíz A;S/I;67539
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1574
dc.pagina.inicio1571
dc.publisherELSEVIER SCIENCE INC
dc.revistaTRANSPLANTATION PROCEEDINGS
dc.rightsacceso restringido
dc.subjectIMPROVES PREVENTION
dc.subjectNEUTROPHILS
dc.subjectINHIBITION
dc.subjectCASCADE
dc.subjectKIDNEY
dc.subjectDAMAGE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePrevention of renal ischemic reperfusion injury using FTY 720 and ICAM-1 antisense oligonucleotides
dc.typeartículo
dc.volumen35
sipa.codpersvinculados67539
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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