Quantification of myocardial scar of different etiology using dark- and bright-blood late gadolinium enhancement cardiovascular magnetic resonance

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dc.article.number5395
dc.catalogadorjlo
dc.contributor.authorJada, Lamis
dc.contributor.authorHoltackers, Robert J .
dc.contributor.authorMartens, Bibi
dc.contributor.authorNies, Hedwig M. J. M.
dc.contributor.authorVan De Heyning, Caroline M.
dc.contributor.authorBotnar, René Michael
dc.contributor.authorWildberger, Joachim E.
dc.contributor.authorIsmail, Tevfik
dc.contributor.authorRazavi, Reza
dc.contributor.authorChiribiri, Amedeo
dc.date.accessioned2024-08-22T16:04:53Z
dc.date.available2024-08-22T16:04:53Z
dc.date.issued2024
dc.description.abstractDark-blood late gadolinium enhancement (LGE) has been shown to improve the visualization and quantification of areas of ischemic scar compared to standard bright-blood LGE. Recently, the performance of various semi-automated quantification methods has been evaluated for the assessment of infarct size using both dark-blood LGE and conventional bright-blood LGE with histopathology as a reference standard. However, the impact of this sequence on different quantification strategies in vivo remains uncertain. In this study, various semi-automated scar quantification methods were evaluated for a range of different ischemic and non-ischemic pathologies encountered in clinical practice. A total of 62 patients referred for clinical cardiovascular magnetic resonance (CMR) were retrospectively included. All patients had a confirmed diagnosis of either ischemic heart disease (IHD; n = 21), dilated/non-ischemic cardiomyopathy (NICM; n = 21), or hypertrophic cardiomyopathy (HCM; n = 20) and underwent CMR on a 1.5 T scanner including both bright- and dark-blood LGE using a standard PSIR sequence. Both methods used identical sequence settings as per clinical protocol, apart from the inversion time parameter, which was set differently. All short-axis LGE images with scar were manually segmented for epicardial and endocardial borders. The extent of LGE was then measured visually by manual signal thresholding, and semi-automatically by signal thresholding using the standard deviation (SD) and the full width at half maximum (FWHM) methods. For all quantification methods in the IHD group, except the 6 SD method, dark-blood LGE detected significantly more enhancement compared to bright-blood LGE (p < 0.05 for all methods). For both bright-blood and dark-blood LGE, the 6 SD method correlated best with manual thresholding (16.9% vs. 17.1% and 20.1% vs. 20.4%, respectively). For the NICM group, no significant differences between LGE methods were found. For bright-blood LGE, the 5 SD method agreed best with manual thresholding (9.3% vs. 11.0%), while for dark-blood LGE the 4 SD method agreed best (12.6% vs. 11.5%). Similarly, for the HCM group no significant differences between LGE methods were found. For bright-blood LGE, the 6 SD method agreed best with manual thresholding (10.9% vs. 12.2%), while for dark-blood LGE the 5 SD method agreed best (13.2% vs. 11.5%). Semi-automated LGE quantification using dark-blood LGE images is feasible in both patients with ischemic and non-ischemic scar patterns. Given the advantage in detecting scar in patients with ischemic heart disease and no disadvantage in patients with non-ischemic scar, dark-blood LGE can be readily and widely adopted into clinical practice without compromising on quantification.
dc.fechaingreso.objetodigital2024-08-22
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1038/s41598-024-52058-8
dc.identifier.urihttps://doi.org/10.1038/s41598-024-52058-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87601
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Botnar, René Michael; 0000-0003-2811-2509; 1015313
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaNature: scientific reports
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleQuantification of myocardial scar of different etiology using dark- and bright-blood late gadolinium enhancement cardiovascular magnetic resonance
dc.typeartículo
dc.volumen14
sipa.codpersvinculados1015313
sipa.trazabilidadORCID;2024-03-11
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