Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease

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dc.catalogadorjlo
dc.contributor.authorVejar, Sebastián
dc.contributor.authorOyarzún Isamitt, Juan Esteban
dc.contributor.authorRetamal, Mauricio A.
dc.contributor.authorOrtiz, Fernando C.
dc.contributor.authorOrellana Roca, Juan Andrés
dc.date.accessioned2024-10-14T18:54:31Z
dc.date.available2024-10-14T18:54:31Z
dc.date.issued2019
dc.description.abstractOligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper synaptic transmission and plasticity at the CNS. The latter requires a fine coordinated intercellular communication with neurons and other glial cell types, including astrocytes. In mammals, tissue synchronization is mainly mediated by connexins and pannexins, two protein families that underpin the communication among neighboring cells through the formation of different plasma membrane channels. At one end, gap junction channels (GJCs; which are exclusively formed by connexins in vertebrates) connect the cytoplasm of contacting cells allowing electrical and metabolic coupling. At the other end, hemichannels and pannexons (which are formed by connexins and pannexins, respectively) communicate the intra-and extracellular compartments, serving as diffusion pathways of ions and small molecules. Here, we briefly review the current knowledge about the expression and function of hemichannels, pannexons and GJCs in oligodendrocytes, as well as the evidence regarding the possible role of these channels in metabolic and synaptic functions at the CNS. In particular, we focus on oligodendrocyte-astrocyte coupling during axon metabolic support and its implications in brain health and disease.
dc.fechaingreso.objetodigital2024-10-14
dc.format.extent10 páginas
dc.fuente.origenConveris
dc.identifier.doi10.3389/fncel.2019.00003
dc.identifier.issn1662-5102
dc.identifier.pubmedidMEDLINE:30760982
dc.identifier.urihttps://doi.org/10.3389/fncel.2019.00003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88199
dc.identifier.wosidWOS:000457201000001
dc.information.autorucEscuela de Medicina; Oyarzún Isamitt, Juan Esteban; 0000-0002-9695-7207; 171970
dc.information.autorucEscuela de Medicina; Orellana Roca, Juan Andrés; 0000-0003-4076-207X; 126007
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaFrontiers in cellular neuroscience
dc.rightsacceso abierto
dc.subjectConnexons
dc.subjectOligodendrocytes
dc.subjectPannexons
dc.subjectHemichannels
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleConnexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease
dc.typeartículo de revisión
dc.volumen13
sipa.codpersvinculados171970
sipa.codpersvinculados126007
sipa.trazabilidadConveris;20-07-2021
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