Is my patient a bleeder? A diagnostic framework for mild bleeding disorders

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dc.contributor.authorQuiroga, Teresa
dc.contributor.authorMezzano, Diego
dc.date.accessioned2024-01-10T13:14:08Z
dc.date.available2024-01-10T13:14:08Z
dc.date.issued2012
dc.description.abstractCongenital mild bleeding disorders (MBDs) are very prevalent and are the source of frequent diagnostic problems. Most MBDs are categorized as disorders of primary hemostasis (ie, type 1 VWD and platelet function disorders), but mild or moderate deficiencies of clotting factors and some rare hyperfibrinolytic disorders are also included. These patients have abnormal bleeding from the skin and mucous membranes, menorrhagia, and disproportionate hemorrhages after trauma, invasive procedures, and surgery. This review addresses the main problems that physicians and hemostasis laboratories confront with the diagnosis of these patients, including: discerning normal/appropriate from pathological bleeding, the role and yield of screening tests, the lack of distinctive bleeding pattern among the different diseases, the inherent difficulties in the diagnosis of type 1 VWD and the most common platelet functional disorders, improvements in assays to measure platelet aggregation and secretion, and the evidence that most of the patients with MBDs end up without a definite diagnosis after exhaustive and repeated laboratory testing. Much research is needed to determine the pathogenesis of bleeding in MBD patients. Better standardization of current laboratory assays, progress in the knowledge of fibrinolytic mechanisms and their laboratory evaluation, and new understanding of the factors contributing to platelet-vessel wall interaction, along with the corresponding development of laboratory tools, should improve our capacity to diagnose a greater proportion of patients with MBDs.
dc.fechaingreso.objetodigital2024-05-10
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1182/asheducation-2012.1.466
dc.identifier.eissn1520-4383
dc.identifier.issn1520-4391
dc.identifier.pubmedidMEDLINE:23233621
dc.identifier.urihttps://doi.org/10.1182/asheducation-2012.1.466
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78377
dc.identifier.wosidWOS:000323755900069
dc.information.autorucMedicina;Diego Mezzano;S/I;99455
dc.information.autorucMedicina;Teresa Quiroga;S/I;52601
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final474
dc.pagina.inicio466
dc.publisherAMER SOC HEMATOLOGY
dc.revistaHEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM
dc.rightsregistro bibliográfico
dc.subjectVON-WILLEBRAND-DISEASE
dc.subjectLIGHT TRANSMISSION AGGREGOMETRY
dc.subjectADENOSINE-TRIPHOSPHATE RELEASE
dc.subjectSTORAGE POOL DEFICIENCY
dc.subjectPLATELET-FUNCTION
dc.subjectINHERITED DEFECTS
dc.subjectRISK-FACTORS
dc.subjectFACTOR-XIII
dc.subjectPFA-100(R)
dc.subjectGUIDELINES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIs my patient a bleeder? A diagnostic framework for mild bleeding disorders
dc.typeartículo
sipa.codpersvinculados99455
sipa.codpersvinculados52601
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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