Clinicopathologic implications of <i>hMSH2</i> gene expression and microsatellite instability in prostate cancer

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dc.contributor.authorVelasco, A
dc.contributor.authorAlbert, PS
dc.contributor.authorRosenberg, H
dc.contributor.authorMartinez, C
dc.contributor.authorLeach, FS
dc.date.accessioned2025-01-21T01:30:23Z
dc.date.available2025-01-21T01:30:23Z
dc.date.issued2002
dc.description.abstractHuman mismatch repair (MMR) genes encode highly conserved interacting proteins that correct replication errors predisposing to hereditary gastrointestinal and genitourinary malignancies. We previously investigated expression of the prototype MMR gene hMSH2 in normal, benign prostatic hyperplasia and malignant prostate tissues (Velasco et al., Cancer 94:690-699, 2002). An association was detected between reduced. hMSH2 staining and favorable outcome as determined by undetectable serum prostate specific antigen (PSA) after radical prostatectomy. We now investigate the association between clinicopathological variables and hMSH2 expression or microsatellite instability (MSI). A statistically significant association was found between tumors exhibiting MSI (MSI+ tumors) and lower preoperative serum PSA values, smaller tumor volumes and lower frequency of surgical specimens with extracapsular extension of tumor. No statistically of significant association (P value less than or equal to 0.05) was found between hMSH2 staining and these clinicopathologic variables. Based on our analysis, we conclude that MMR deficiency has important clinicopathologic implications in prostate cancer. Furthermore, specific MMR genes may have different effects on prostate cancer biology.
dc.fuente.origenWOS
dc.identifier.eissn1555-8576
dc.identifier.issn1538-4047
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96726
dc.identifier.wosidWOS:000180996300008
dc.issue.numero4
dc.language.isoen
dc.pagina.final367
dc.pagina.inicio362
dc.revistaCancer biology & therapy
dc.rightsacceso restringido
dc.subjecthMSH2 gene expression
dc.subjectmicrosatellite instability
dc.subjectprostate cancer
dc.subjectmismatch repair
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinicopathologic implications of <i>hMSH2</i> gene expression and microsatellite instability in prostate cancer
dc.typeartículo
dc.volumen1
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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