3D joint T 1/T 1 ρ/T 2 mapping and water-fat imaging for contrast-agent free myocardial tissue characterization at 1.5T.

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dc.catalogadorgjm
dc.contributor.authorCrabb, Michael G.
dc.contributor.authorKunze, Karl P.
dc.contributor.authorLittlewood, Simon J.
dc.contributor.authorTripp, Donovan
dc.contributor.authorFotaki, Anastasia
dc.contributor.authorPrieto Vásquez, Claudia
dc.contributor.authorBotnar, René Michael
dc.date.accessioned2025-03-17T14:35:58Z
dc.date.available2025-03-17T14:35:58Z
dc.date.issued2025
dc.description.abstractPURPOSE: To develop a novel, free-breathing, 3D joint T 1 $$ {T}_1 $$ / T 1 ρ $$ {T}_{1\rho } $$ / T 2 $$ {T}_2 $$ mapping sequence with Dixon encoding to provide co-registered 3D T 1 $$ {T}_1 $$ , T 1 ρ $$ {T}_{1\rho } $$ , and T 2 $$ {T}_2 $$ maps and water-fat volumes with isotropic spatial resolution in a single ≈ 7 $$ \approx 7 $$ min scan for comprehensive contrast-agent-free myocardial tissue characterization and simultaneous evaluation of the whole-heart anatomy. METHODS: An interleaving sequence over 5 heartbeats is proposed to provide T 1 $$ {T}_1 $$ , T 1 ρ $$ {T}_{1\rho } $$ , and T 2 $$ {T}_2 $$ encoding, with 3D data acquired with Dixon gradient-echo readout and 2D image navigators to enable 100 % $$ 100\% $$ respiratory scan efficiency. Images were reconstructed with a non-rigid motion-corrected, low-rank patch-based reconstruction, and maps were generated through dictionary matching. The proposed sequence was compared against conventional 2D techniques in phantoms, 10 healthy subjects, and 1 patient. RESULTS: The proposed 3D T 1 $$ {T}_1 $$ , T 1 ρ $$ {T}_{1\rho } $$ , and T 2 $$ {T}_2 $$ measurements showed excellent correlation with 2D reference measurements in phantoms. For healthy subjects, the mapping values of septal myocardial tissue were T 1 = 1060 ± 48 ms $$ {T}_1=1060\pm 48\kern0.2778em \mathrm{ms} $$ , T 1 ρ = 48 . 1 ± 3 . 9 ms $$ {T}_{1\rho }=48.1\pm 3.9\kern0.2778em \mathrm{ms} $$ , and T 2 = 44 . 2 ± 3 . 2 ms $$ {T}_2=44.2\pm 3.2\kern0.2778em \mathrm{ms} $$ for the proposed sequence, against T 1 = 959 ± 15 ms $$ {T}_1=959\pm 15\kern0.2778em \mathrm{ms} $$ , T 1 ρ = 56 . 4 ± 1 . 9 ms $$ {T}_{1\rho }=56.4\pm 1.9\kern0.2778em \mathrm{ms} $$ , and T 2 = 47 . 3 ± 1 . 5 ms $$ {T}_2=47.3\pm 1.5\kern0.2778em \mathrm{ms} $$ for 2D MOLLI, 2D T 1 ρ $$ {T}_{1\rho } $$ -prep bSSFP and 2D T 2 $$ {T}_2 $$ -prep bSSFP, respectively. Promising results were obtained when comparing the proposed mapping to 2D references in 1 patient with active myocarditis. CONCLUSION: The proposed approach enables simultaneous 3D whole-heart joint T 1 $$ {T}_1 $$ / T 1 ρ $$ {T}_{1\rho } $$ / T 2 $$ {T}_2 $$ mapping and water/fat imaging in ≈ $$ \approx $$ 7 min scan time, demonstrating good agreement with conventional mapping techniques in phantoms and healthy subjects and promising results in 1 patient with suspected cardiovascular disease.
dc.fechaingreso.objetodigital2025-03-17
dc.format.extent14 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1002/mrm.30397
dc.identifier.issn0740-3194
dc.identifier.urihttps://doi.org/10.1002/mrm.30397
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102661
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia; 0000-0003-4602-2523; 14195
dc.information.autorucEscuela de Ingeniería; Botnar, René Michael; 0000-0003-2811-2509; 1015313
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaMagnetic Resonance in Medicine
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectT1𝜌 mapping
dc.subjectT1 mapping
dc.subjectT2 mapping
dc.subject3D multi-parametric MRI
dc.subjectCardiac MRI
dc.subjectMyocardialtissue characterisation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.title3D joint T 1/T 1 ρ/T 2 mapping and water-fat imaging for contrast-agent free myocardial tissue characterization at 1.5T.
dc.typeartículo
sipa.codpersvinculados14195
sipa.codpersvinculados1015313
sipa.trazabilidadORCID;2025-03-03
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