Adenomyomas of the Gallbladder An Analysis of Frequency, Clinicopathologic Associations, and Relationship to Carcinoma of a Malformative Lesion

Simple item page
dc.contributor.authorDursun, Nevra
dc.contributor.authorMemis, Bahar
dc.contributor.authorPehlivanoglu, Burcin
dc.contributor.authorTaskin, Orhun Cig
dc.contributor.authorOkcu, Oguzhan
dc.contributor.authorAkkas, Gizem
dc.contributor.authorBagci, Pelin
dc.contributor.authorBalci, Serdar
dc.contributor.authorSaka, Burcu
dc.contributor.authorAraya, Juan Carlos
dc.contributor.authorBellolio, Enrique
dc.contributor.authorRoa, Juan Carlos
dc.contributor.authorJang, Kee-Taek
dc.contributor.authorLosada, Hector
dc.contributor.authorMaithel, Shishir K.
dc.contributor.authorSarmiento, Juan
dc.contributor.authorReid, Michelle D.
dc.contributor.authorJang, Jin-Young
dc.contributor.authorCheng, Jeanette D.
dc.contributor.authorBasturk, Olca
dc.contributor.authorKoshiol, Jill
dc.contributor.authorAdsay, N. Volkan
dc.date.accessioned2025-01-20T17:09:10Z
dc.date.available2025-01-20T17:09:10Z
dc.date.issued2024
dc.description.abstractContext.-The nature and associations of gallbladder (GB) "adenomyoma"(AM) remain controversial. Some studies have attributed up to 26% of GB carcinoma to AMs. Objective.-To examine the true frequency, clinicopathologic characteristics, and neoplastic changes in GB AM. Design.-Cholecystectomy cohorts analyzed were 1953 consecutive cases, prospectively with specific attention to AM; 2347 consecutive archival cases; 203 totally embedded GBs; 207 GBs with carcinoma; and archival search of institutions for all cases diagnosed as AM. Results.-Frequency of AM was 9.3% (19 of 203) in totally submitted cases but 3.3% (77 of 2347) in routinely sampled archival tissue. A total of 283 AMs were identified, with a female to male ratio =1.9 (177:94) and mean size = 1.3 cm (range, 0.3-5.9). Most (96%, 203 of 210) were fundic, with formed nodular trabeculated submucosal thickening, and were difficult to appreciate from the mucosal surface. Four of 257 were multifocal (1.6%), and 3 of 257 (1.2%) were extensive ("adenomyomatosis"). Dilated glands (up to 14 mm), often radially converging to a point in the mucosa, were typical. Muscle was often minimal, confined to the upper segment. Nine of 225 (4%) revealed features of a duplication. No specific associations with inflammation, cholesterolosis, intestinal metaplasia, or thickening of the uninvolved GB wall were identified. Neoplastic change arising in AM was seen in 9.9% (28 of 283). Sixteen of 283 (5.6%) had mural intracholecystic neoplasm; 7 of 283 (2.5%) had flat -type high-grade dysplasia/carcinoma in situ. Thirteen of 283 cases had both AM and invasive carcinoma (4.6%), but in only 5 of 283 (1.8%), carcinoma arose from AM (invasion was confined to AM, and dysplasia was predominantly in AM). Conclusions.-AMs have all the features of a malformative developmental lesion, and may not show a significant muscle component (ie, the name "adeno-myoma"is partly a misnomer). While most are innocuous, some pathologies may arise in AMs, including intracholecystic neoplasms, flattype high-grade dysplasia or carcinoma in situ, and invasive carcinoma (1.8%, 5 of 283). It is recommended that gross examination of GBs include serial slicing of the fundus for AM detection and total submission if one is found.
dc.description.funderNational Cancer Institute
dc.fuente.origenWOS
dc.identifier.doi10.5858/arpa.2022-0379-OA
dc.identifier.eissn1543-2165
dc.identifier.issn0003-9985
dc.identifier.urihttps://doi.org/10.5858/arpa.2022-0379-OA
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91018
dc.identifier.wosidWOS:001156379700011
dc.issue.numero2
dc.language.isoen
dc.pagina.final214
dc.pagina.inicio206
dc.revistaArchives of pathology & laboratory medicine
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdenomyomas of the Gallbladder An Analysis of Frequency, Clinicopathologic Associations, and Relationship to Carcinoma of a Malformative Lesion
dc.typeartículo
dc.volumen148
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Adenomyomas of the Gallbladder.pdf
Size:
2.48 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas