Unraveling the role of micrornas in mycobacterium tuberculosis infection and disease: advances and pitfalls

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dc.article.numbere00649-19
dc.catalogadorpva
dc.contributor.authorRuiz-Tagle, Cinthya
dc.contributor.authorNaves, Rodrigo
dc.contributor.authorBalcells Marty, María Elvira
dc.date.accessioned2023-11-10T18:58:55Z
dc.date.available2023-11-10T18:58:55Z
dc.date.issued2020
dc.description.abstractTuberculosis (TB) is an infectious disease of extremely high epidemiological burden worldwide that is easily acquired through the inhalation of infected respiratory droplets. The complex pathogenesis of this infection spans from subjects never developing this disease despite intense exposure, to others in which immune containment fails catastrophically and severe or disseminated forms of disease ensue. In recent decades, microRNAs (miRNAs) have gained increasing attention due to their role as gene silencers and because of their altered expression in diverse human diseases, including some infections. Recent research regarding miRNAs and TB has revealed that the expression profile for particular miRNAs clearly changes upon Mycobacterium tuberculosis infection and also varies in the different stages of this disease. However, despite the growing number of studies - some of which have even proposed some miRNAs as potential biomarkers - methodological variations and key differences in relevant factors, such as sex and age, cell type analyzed, M. tuberculosis strain, and antimicrobial therapy status, strongly hinder the comparison of data. In this review, we summarize and discuss the literature and highlight the role of selected miRNAs that have specifically and more consistently been associated with M. tuberculosis infection, together with a discussion of the possible gene and immune regulation pathways involved.
dc.description.funderComisión Nacional de Investigación Científica y Tecnológica
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2023-10-11
dc.fuente.origenScopus
dc.identifier.doi10.1128/IAI.00649-19
dc.identifier.eissn1098-5522
dc.identifier.issn10985522 00199567
dc.identifier.pubmedidMEDLINE:31871103
dc.identifier.scopusidSCOPUS_ID:85081143882
dc.identifier.scopusid000514850300025
dc.identifier.urihttps://doi.org/10.1128/IAI.00649-19
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75293
dc.identifier.wosidWOS:000514850300025
dc.information.autorucEscuela de Medicina; Ruiz-Tagle, Cinthya; ; 1098594
dc.information.autorucEscuela de Medicina; Balcells Marty, María Elvira; 0000-0002-7223-9665; 7462
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final17
dc.pagina.inicio1
dc.publisherAmerican Society for Microbiology
dc.revistaInfection and Immunityes_ES
dc.rightsacceso abierto
dc.subjectTuberculosises_ES
dc.subjectMiRNAes_ES
dc.subjectBiomarkeres_ES
dc.subjectMycobacterium tuberculosises_ES
dc.subjectInfectiones_ES
dc.subjectDiseasees_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleUnraveling the role of micrornas in mycobacterium tuberculosis infection and disease: advances and pitfallses_ES
dc.typeartículo de revisión
dc.volumen88
sipa.codpersvinculados1098594
sipa.codpersvinculados7462
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