A Mathematical Model of Thyroid Disease Response to Radiotherapy

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dc.contributor.authorGago-Arias, Araceli
dc.contributor.authorNeira, Sara
dc.contributor.authorTerragni, Filippo
dc.contributor.authorPardo-Montero, Juan
dc.date.accessioned2025-01-20T22:02:48Z
dc.date.available2025-01-20T22:02:48Z
dc.date.issued2021
dc.description.abstractWe present a mechanistic biomathematical model of molecular radiotherapy of thyroid disease. The general model consists of a set of differential equations describing the dynamics of different populations of thyroid cells with varying degrees of damage caused by radiotherapy (undamaged cells, sub-lethally damaged cells, doomed cells, and dead cells), as well as the dynamics of thyroglobulin and antithyroglobulin autoantibodies, which are important surrogates of treatment response. The model is presented in two flavours: on the one hand, as a deterministic continuous model, which is useful to fit populational data, and on the other hand, as a stochastic Markov model, which is particularly useful to investigate tumor control probabilities and treatment individualization. The model was used to fit the response dynamics (tumor/thyroid volumes, thyroglobulin and antithyroglobulin autoantibodies) observed in experimental studies of thyroid cancer and Graves' disease treated with I-131-radiotherapy. A qualitative adequate fitting of the model to the experimental data was achieved. We also used the model to investigate treatment individualization strategies for differentiated thyroid cancer, aiming to improve the tumor control probability. We found that simple individualization strategies based on the absorbed dose in the tumor and tumor radiosensitivity (which are both magnitudes that can potentially be individually determined for every patient) can lead to an important raise of tumor control probabilities.
dc.fuente.origenWOS
dc.identifier.doi10.3390/math9192365
dc.identifier.eissn2227-7390
dc.identifier.urihttps://doi.org/10.3390/math9192365
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94004
dc.identifier.wosidWOS:000747706700001
dc.issue.numero19
dc.language.isoen
dc.revistaMathematics
dc.rightsacceso restringido
dc.subjectradioiodine therapy
dc.subjectradiobiology
dc.subjectthyroid
dc.subjectmathematical model
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA Mathematical Model of Thyroid Disease Response to Radiotherapy
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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