Vitamin D and cathelicidin levels and susceptibility to Mycobacterium tuberculosis infection acquisition in household contactsNiveles de vitamina D y catelicidina y susceptibilidad a la infección por Mycobacterium tuberculosis en contactos intradomiciliarios

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dc.catalogadorvzp
dc.contributor.authorRuiz-tagle Seguel Cinthya Grace
dc.contributor.authorRomero, Francisco
dc.contributor.authorNaves Pichuante, Rodrigo Antonio
dc.contributor.authorBalcells Marty, Maria Elvira
dc.date.accessioned2023-11-10T16:13:27Z
dc.date.available2023-11-10T16:13:27Z
dc.date.issued2022
dc.description.abstractIntroduction: Vitamin D deficiency has been proposed to confer susceptibility to acquiring tuberculosis infection by impairing the innate immune response. Methods: In an exploratory study, we examined whether the levels of 25-hydroxyvitamin D3 (25(OH)D3) in serum, and cathelicidin – an antimicrobial peptide-induced under calcitriol – in the nasal fluid, would associate with the risk of acquiring tuberculosis infection. Results: Within a prospective cohort of 231 tuberculosis household contacts tested with repeated interferon-gamma release assays, we serially analyzed all the uninfected contacts acquiring tuberculosis infection at follow-up (“converters”, n = 18), and an age and sex-matched control group of contacts not acquiring tuberculosis infection (“non-converters”, n = 36). The median levels of serum 25(OH)D3 did not differ between convertors and non-converters at baseline (14.9 vs. 13.2 ng/ml, p = 0.41), nor at follow-up (19.0 vs 18.6 ng/ml, p = 0.83). Similarly, cathelicidin levels did not differ between both groups. Conclusion: These data argue against a major role for hypovitaminosis D in tuberculosis infection susceptibility. © 2022 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica
dc.description.funderCONICYT
dc.description.funderANID
dc.fechaingreso.objetodigital2023-11-10
dc.format.extent5 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.eimc.2022.04.016
dc.identifier.eissn15781852
dc.identifier.issn0213005X
dc.identifier.scopusidSCOPUS_ID:85131577648
dc.identifier.urihttps://seimc.org/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75277
dc.information.autorucEscuela de Medicina; Ruiz-tagle Seguel Cinthya Grace; 0000-0002-4712-3302; 1098594
dc.information.autorucEscuela de Medicina; Naves Pichuante Rodrigo Antonio; 0000-0002-1203-3593; 200771
dc.information.autorucEscuela de Medicina; Balcells Marty Maria Elvira; 0000-0002-7223-9665; 7462
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final493
dc.pagina.inicio489
dc.publisherSociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica
dc.relation.ispartofEnfermedades Infecciosas y Microbiologia Clinica
dc.revistaEnfermedades Infecciosas y Microbiologia Clinica
dc.rightsacceso restringido
dc.subjectCathelicidin (LL-37)
dc.subjectHousehold contacts
dc.subjectMycobacterium tuberculosis
dc.subjectTuberculosis
dc.subjectVitamin D
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleVitamin D and cathelicidin levels and susceptibility to Mycobacterium tuberculosis infection acquisition in household contactsNiveles de vitamina D y catelicidina y susceptibilidad a la infección por Mycobacterium tuberculosis en contactos intradomiciliarios
dc.typeartículo
dc.volumen41
sipa.codpersvinculados1098594
sipa.codpersvinculados200771
sipa.codpersvinculados7462
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