Effects of Japanese herbal medicine inchin-ko-to on endotoxin-induced cholestasis in the rat

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dc.contributor.authorPablo Arab, Juan
dc.contributor.authorRamirez, Carolina
dc.contributor.authorMunoz, Pablo
dc.contributor.authorPizarro, Margarita
dc.contributor.authorSolis, Nancy
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorArrese, Marco
dc.date.accessioned2024-01-10T12:38:37Z
dc.date.available2024-01-10T12:38:37Z
dc.date.issued2009
dc.description.abstractBackground/Objective. Inchin-ko-to (ICKT) is an herbal medicine used in Japan to treat jaundice and liver fibrosis. We investigated the effect of oral ICKT supplementation on endotoxin-induced cholestasis in the rat. Material and methods. Lipopolysaccharide (LPS) injection (1 mg/kg body weight i.p.) was used as a model of sepsis-induced cholestasis. Bite flow, biliary bile salt secretion, biliary glutathione secretion and protein expression of the main hepatobiliary transporters Na(+)-taurocholate-cotransporting peptide (Ntcp), multidrug resistance protein 2 (Mrp2) and bile salt export pump (Bsep) were analyzed by conventional techniques in ICKT treated and non-treated animals. Results. Injection of LIDS induced a significant decrease of bite ftow (-24%), biliary bite salts (-40%) and glutathione excretion (-70%) as well as a significant decrease in Ntcp (-90%) and Mrp2 (-80%) protein levels. ICKT supplementation partially prevented the effects of LIPS determining a less intense reduction in bile flow (-10%), a normalization of glutathione excretion as well as a significant increase in Mrp2 protein levels to 60% of the levels observed in control animals. ICKT administration did not modify the effects of LPS on BS secretion or Ntcp protein levels. Conclusion. Our data show that oral. supplementation of ICKT partially prevents LPS-induced cholestasis by increasing Mrp2 protein levels and biliary glutathione excretion thus increasing bite salt-independent ftow.
dc.description.funderFondo Nacional De Ciencia y Tecnologia de Chile
dc.fechaingreso.objetodigital2024-05-06
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.issn1665-2681
dc.identifier.pubmedidMEDLINE:19841502
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77072
dc.identifier.wosidWOS:000270400300008
dc.information.autorucMedicina;Arab JP;S/I;132745
dc.information.autorucMedicina;Arrese M;S/I;76095
dc.information.autorucMedicina;Pizarro M;S/I;102250
dc.information.autorucMedicina;Riquelme A;S/I;3538
dc.information.autorucMedicina;Solís N;S/I;102379
dc.issue.numero3
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final233
dc.pagina.inicio228
dc.publisherMEXICAN ASSOC HEPATOLOGY
dc.revistaANNALS OF HEPATOLOGY
dc.rightsregistro bibliográfico
dc.subjectInchin-ko-to
dc.subjectCholestasis
dc.subjectEndotoxin
dc.subjectGenipin
dc.subjectBILIARY ATRESIA PATIENTS
dc.subjectORGANIC ANION TRANSPORT
dc.subjectLIVER FIBROSIS
dc.subjectBILE FORMATION
dc.subjectEXPORT PUMP
dc.subjectTJ-135
dc.subjectACID
dc.subjectINFLAMMATION
dc.subjectGLUTATHIONE
dc.subjectMECHANISMS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of Japanese herbal medicine inchin-ko-to on endotoxin-induced cholestasis in the rat
dc.typeartículo
dc.volumen8
sipa.codpersvinculados132745
sipa.codpersvinculados76095
sipa.codpersvinculados102250
sipa.codpersvinculados3538
sipa.codpersvinculados102379
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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