Prognostic factors in de novo metastatic renal cell carcinoma: A report from the latin american renal cancer group

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dc.contributor.authorAbreu D.
dc.contributor.authorDecia R.
dc.contributor.authorCarvalhal G.
dc.contributor.authorGueglio G.
dc.contributor.authorTobia I.
dc.contributor.authorGarcia P.
dc.contributor.authorZuñiga A.
dc.contributor.authorMeza L.
dc.contributor.authorBengio R.
dc.contributor.authorScorticati C.
dc.contributor.authorCastillejos R.
dc.contributor.authorRodriguez F.
dc.contributor.authorAutran A.M.
dc.contributor.authorGonzales C.
dc.contributor.authorGadu J.
dc.contributor.authorNolazco A.
dc.contributor.authorAmeri C.
dc.contributor.authorZampolli H.
dc.contributor.authorLangenhin R.
dc.contributor.authorMuguruza D.
dc.contributor.authorMachado M.T.
dc.contributor.authorMingote P.
dc.contributor.authorYandian J.
dc.contributor.authorClavijo J.
dc.contributor.authorNogueira L.
dc.contributor.authorClark O.
dc.contributor.authorSecin F.
dc.contributor.authorRovegno A.
dc.contributor.authorVilas A.
dc.contributor.authorBarrios E.
dc.contributor.authorGuimarães G.
dc.contributor.authorZequi S.C.
dc.contributor.authorGlina S.
dc.contributor.authorPal S.K.
dc.contributor.authorRodriguez O.
dc.contributor.authorPalou J.
dc.contributor.authorSpiess P.
dc.contributor.authorLara P.N.
dc.contributor.authorMarston Linehan W.
dc.contributor.authorPastore A.L.
dc.date.accessioned2024-01-10T14:23:44Z
dc.date.available2024-01-10T14:23:44Z
dc.date.issued2021
dc.description.abstract© 2021 by American Society of Clinical Oncology.PURPOSE To assess the effect of clinical and pathological variables on cancer-specific and overall survival (OS) in de novo metastatic patients from a collaborative of primarily Latin American countries. PATIENTS AND METHODS Of 4,060 patients with renal cell carcinoma diagnosed between 1990 and 2015, a total of 530 (14.5%) had metastasis at clinical presentation. Relationships between clinical and pathological parameters and treatment-related outcomes were analyzed by Cox regression and the log-rank method. RESULTS Of 530 patients, 184 (90.6%) had died of renal cell carcinoma. The median OS of the entire cohort was 24 months. American Society of Anesthesiology classification 3-4 (hazard ratio [HR]: 1.64), perirenal fat invasion (HR: 2.02), and ≥ 2 metastatic organ sites (HR: 2.19) were independent prognostic factors for 5-year OS in multivariable analyses. We created a risk group stratification with these variables: no adverse risk factors (favorable group), median OS not reached; one adverse factor (intermediate group), median OS 33 months (HR: 2.04); and two or three adverse factors (poor risk group), median OS 14 months (HR: 3.58). CONCLUSION Our study defines novel prognostic factors that are relevant to a Latin American cohort. With external validation, these easily discerned clinical variables can be used to offer prognostic information across low- and middle-income countries.
dc.fechaingreso.objetodigital2024-05-15
dc.fuente.origenScopus
dc.identifier.doi10.1200/GO.20.00621
dc.identifier.eissn26878941
dc.identifier.issn26878941
dc.identifier.pubmedid33974442
dc.identifier.scopusidSCOPUS_ID:85105769181
dc.identifier.urihttps://doi.org/10.1200/GO.20.00621
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80135
dc.information.autorucFacultad de Medicina; Rovegno Echavarria, David Maximiliano; S/I; 1004053
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final685
dc.pagina.inicio671
dc.publisherAmerican Society of Clinical Oncology
dc.revistaJCO Global Oncology
dc.rightsregistro bibliográfico
dc.titlePrognostic factors in de novo metastatic renal cell carcinoma: A report from the latin american renal cancer group
dc.typeartículo de revisión
dc.volumen7
sipa.codpersvinculados1004053
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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