Comparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis

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dc.contributor.authorBarron Montenegro, Rocio
dc.contributor.authorGarcia, Rodrigo
dc.contributor.authorDuenas, Fernando
dc.contributor.authorRivera, Dacil
dc.contributor.authorOpazo Capurro, Andres
dc.contributor.authorErickson, Stephen
dc.contributor.authorMoreno Switt, Andrea, I
dc.date.accessioned2024-01-10T12:36:58Z
dc.date.available2024-01-10T12:36:58Z
dc.date.issued2021
dc.description.abstractSalmonella spp. is one of the most common foodborne pathogens worldwide; therefore, its control is highly relevant for the food industry. Phages of the Felixounavirus genus have the characteristic that one phage can infect a large number of different Salmonella serovars and, thus, are proposed as an alternative to antimicrobials in food production. Here, we describe two new members of the Felixounavirus genus named vB_Si_35FD and vB_Si_DR94, which can infect Salmonella Infantis. These new members were isolated and sequenced, and a subsequent comparative genomic analysis was conducted including 23 publicly available genomes of Felixounaviruses that infect Salmonella. The genomes of vB_Si_35FD and vB_Si_DR94 are 85,818 and 85,730 bp large and contain 129 and 125 coding sequences, respectively. The genomes did not show genes associated with virulence or antimicrobial resistance, which could be useful for candidates to use as biocontrol agents. Comparative genomics revealed that closely related Felixounavirus are found in distinct geographical locations and that this genus has a conserved genomic structure despite its worldwide distribution. Our study revealed a highly conserved structure of the phage genomes, and the two newly described phages could represent promising biocontrol candidates against Salmonella spp. from a genomic viewpoint.
dc.description.funderANID FONDECYT
dc.description.funderANID Millennium Science Initiative/Millennium Initiative for Collaborative Research on Bacterial Resistance
dc.description.funderBBSRC
dc.description.funderCONICYT FECHA DOCTORADO/2016
dc.fechaingreso.objetodigital2024-05-03
dc.format.extent15 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3390/antibiotics10070806
dc.identifier.issn2079-6382
dc.identifier.pubmedidMEDLINE:34356727
dc.identifier.urihttps://doi.org/10.3390/antibiotics10070806
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76711
dc.identifier.wosidWOS:000686143100001
dc.information.autorucFacultad de Agronomía e Ingeniería Forestal; Moreno Switt, Andrea Isabel; S/I; 1147061
dc.issue.numero7
dc.language.isoen
dc.nota.accesoSin adjunto
dc.publisherMDPI
dc.revistaANTIBIOTICS-BASEL
dc.rightsregistro bibliográfico
dc.subjectbacteriophages
dc.subjectgenomes
dc.subjectFelixounavirus
dc.subjectSalmonella spp
dc.subjectSalmonella phages
dc.subjectcomparative genomics
dc.subjectPHAGE
dc.subjectGENES
dc.subjectFARMS
dc.subjectBACTERIOPHAGES
dc.subjectENDONUCLEASE
dc.subjectSEQUENCE
dc.subjectVIRUSES
dc.subjectFOOD
dc.titleComparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis
dc.typeartículo
dc.volumen10
sipa.codpersvinculados1147061
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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