Four-month-old with severe <i>PIK3CA</i>-related overgrowth spectrum disorder successfully treated with alpelisb
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Date
2024
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Abstract
PIK3CA-related overgrowth spectrum (PROS) encompasses different clinical entities caused by somatic activating mutations in PIK3CA. Among PROS, CLOVES syndrome represents a severe phenotype with poor survival rate. We present the case of a 4-month-old girl with CLOVES syndrome successfully treated with alpelisib, a PIKC3A inhibitor.
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Keywords
pharmacotherapy, vascular anomalies, vascular malformations