Single breath-hold assessment of cardiac function using an accelerated 3D single breath-hold acquisition technique - comparison of an intravascular and extravascular contrast agent

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dc.contributor.authorMakowski, Marcus R.
dc.contributor.authorWiethoff, Andrea J.
dc.contributor.authorJansen, Christian H.
dc.contributor.authorUribe Arancibia, Sergio A.
dc.contributor.authorParish, Victoria.
dc.contributor.authorSchuster, Andreas.
dc.contributor.authorBotnar, René Michael
dc.contributor.authorBell, Aaron.
dc.contributor.authorKiesewetter, Christoph.
dc.contributor.authorRazavi, Reza.
dc.contributor.authorSchaeffter, Tobias.
dc.contributor.authorGreil, Gerald F.
dc.date.accessioned2019-10-17T18:22:04Z
dc.date.available2019-10-17T18:22:04Z
dc.date.issued2012
dc.date.updated2019-10-14T18:58:20Z
dc.description.abstractAbstract Background Cardiovascular magnetic resonance (CMR) is the current gold standard for the assessment of left ventricular (LV) function. Repeated breath-holds are needed for standard multi-slice 2D cine steady-state free precession sequences (M2D-SSFP). Accelerated single breath-hold techniques suffer from low contrast between blood pool and myocardium. In this study an intravascular contrast agent was prospectively compared to an extravascular contrast agent for the assessment of LV function using a single-breath-hold 3D-whole-heart cine SSFP sequence (3D-SSFP). Methods LV function was assessed in fourteen patients on a 1.5 T MR-scanner (Philips Healthcare) using 32-channel coil technology. Patients were investigated twice using a 3D-SSFP sequence (acquisition time 18–25 s) after Gadopentetate dimeglumine (GdD, day 1) and Gadofosveset trisodium (GdT, day 2) administration. Image acquisition was accelerated using sensitivity encoding in both phase encoding directions (4xSENSE). CNR and BMC were both measured between blood and myocardium. The CNR incorporated noise measurements, while the BMC represented the coeffiancy between the signal from blood and myocardium [1]. Contrast to noise ratio (CNR), blood to myocardium contrast (BMC), image quality, LV functional parameters and intra-/interobserver variability were compared. A M2D-SSFP sequence was used as a reference standard on both days. Results All 3D-SSFP sequences were successfully acquired within one breath-hold after GdD and GdT administration. CNR and BMC were significantly (p < 0.05) higher using GdT compared to GdD, resulting in an improved endocardial definition. Using 3D-SSFP with GdT, Bland–Altman plots showed a smaller bias (95% confidence interval LVEF: 9.0 vs. 23.7) and regression analysis showed a stronger correlation to the reference standard (R2 = 0.92 vs. R2 = 0.71), compared to 3D-SSFP with GdD. Conclusions A single-breath-hold 3D-whole-heart cine SSFP sequence in combination with 32-channel technology and an intravascular contrast agent allows for the accurate and fast assessment of LV function. Trial registration The study was approved by the local research ethics committee (Study No. 07/Q0704/2) and was registered with the Medicines and Healthcare Products Regulatory Agency (MHRA Study No. 28482/0002/001–0001, EudraCTnumber 2006–007042).
dc.fuente.origenBiomed Central
dc.identifier.citationJournal of Cardiovascular Magnetic Resonance. 2012 Jul 31;14(1):53
dc.identifier.doi10.1186/1532-429X-14-53
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26831
dc.identifier.wosidWOS:000308554700001
dc.issue.numeroNo.53
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final8
dc.pagina.inicio1
dc.revistaJournal of Cardiovascular Magnetic Resonancees_ES
dc.rightsacceso abierto
dc.rights.holderMakowski et al.; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.subject.otherCorazón - Evaluaciónes_ES
dc.subject.otherCorazón - Imagenes_ES
dc.subject.otherTécnicas de diagnóstico cardiovasculares_ES
dc.subject.otherDiagnóstico por imagenes_ES
dc.subject.otherResonancia magnéticaes_ES
dc.titleSingle breath-hold assessment of cardiac function using an accelerated 3D single breath-hold acquisition technique - comparison of an intravascular and extravascular contrast agentes_ES
dc.typeartículo
dc.volumenVol.14
sipa.codpersvinculados16572
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