Copper nanoparticles supported on zinc oxide as efficient catalyst for the N-Arylation of (Hetero)cyclic and acyclic amides
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Copper nanoparticles (CuNPs) supported on ZnO are highly active and selective heterogeneous catalyst for the N-arylation of cyclic and acyclic amides (Golberg coupling). The reaction conditions are mild, featuring K3PO4 as a base and N,N'-dimethylethylendiamine (DMEDA) as ligand in refluxing acetonitrile. The CuNPs/ZnO catalyst can be recovered and reused in six cycles with only little loss of activity. The methodology can be successfully scaled up to gram scale without decreasing the catalytic activity.
Description
Keywords
Lactams, Amides, N-arylation, Copper nanoparticles, Heterogeneous catalyst, Coupling reactions scope, Aryl halides, C-N, Goldberg reaction, Amidation, Complexes, Amination, Mild, Heterocycles, Bromides