Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia

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dc.contributor.authorChaparro, Alejandra
dc.contributor.authorMonckeberg, Maximiliano
dc.contributor.authorRealini, Ornella
dc.contributor.authorHernandez, Marcela
dc.contributor.authorParam, Fernanda
dc.contributor.authorAlbers, Daniela
dc.contributor.authorRamirez, Valeria
dc.contributor.authorPedro Kusanovic, Juan
dc.contributor.authorRomero, Roberto
dc.contributor.authorRice, Gregory
dc.contributor.authorIllanes, Sebastian E.
dc.date.accessioned2025-01-20T23:50:57Z
dc.date.available2025-01-20T23:50:57Z
dc.date.issued2021
dc.description.abstractEarly and innovative diagnostic strategies are required to predict the risk of developing pre-eclampsia (PE). The purpose of this study was to evaluate the performance of gingival crevicular fluid (GCF) placental alkaline phosphatase (PLAP) concentrations to correctly classify women at risk of PE. A prospectively collected, retrospectively stratified cohort study was conducted, with 412 pregnant women recruited at 11-14 weeks of gestation. Physical, obstetrical, and periodontal data were recorded. GCF and blood samples were collected for PLAP determination by ELISA assay. A multiple logistic regression classification model was developed, and the classification efficiency of the model was established. Within the study cohort, 4.3% of pregnancies developed PE. GCF-PLAP concentration was 3- to 6-fold higher than in plasma samples. GCF-PLAP concentrations and systolic blood pressure were greater in women who developed PE (p = 0.015 and p < 0.001, respectively). The performance of the multiparametric model that combines GCF-PLAP concentration and the levels of systolic blood pressure (at 11-14 weeks gestation) showed an association of systolic blood pressure and GCF-PLAP concentrations with the likelihood of developing PE (OR:1.07; 95% CI 1.01-1.11; p = 0.004 and OR:1.008, 95% CI 1.000-1.015; p = 0.034, respectively). The model had a sensitivity of 83%, a specificity of 72%, and positive and negative predictive values of 12% and 99%, respectively. The area under the receiver operating characteristic (AUC-ROC) curve was 0.77 and correctly classified 72% of PE pregnancies. In conclusion, the multivariate classification model developed may be of utility as an aid in identifying pre-symptomatic women who subsequently develop PE.
dc.fuente.origenWOS
dc.identifier.doi10.3390/diagnostics11040661
dc.identifier.eissn2075-4418
dc.identifier.urihttps://doi.org/10.3390/diagnostics11040661
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94754
dc.identifier.wosidWOS:000642976900001
dc.issue.numero4
dc.language.isoen
dc.revistaDiagnostics
dc.rightsacceso restringido
dc.subjectcohort study
dc.subjectgestation
dc.subjectplacental biomarkers
dc.subjectpre-eclampsia
dc.subjectrisk prediction model
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleGingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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