Brain Natriuretic Peptide (BNP) Produced by the Human Chorioamnion May Mediate Pregnancy Myometrial Quiescence

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dc.contributor.authorCarvajal, Jorge A.
dc.contributor.authorDelpiano, Ana M.
dc.contributor.authorCuello, Mauricio A.
dc.contributor.authorPoblete, Jose A.
dc.contributor.authorCasanello, Paola C.
dc.contributor.authorSobrevia, Luis A.
dc.contributor.authorWeiner, Carl P.
dc.date.accessioned2025-01-21T01:04:54Z
dc.date.available2025-01-21T01:04:54Z
dc.date.issued2009
dc.description.abstractWe aim to demonstrate that Brain Natriuretic Peptide (BNP) is synthesized and released from the fetal membranes and mediates pregnancy myometrial quiescence. Myometrium and fetal membranes (FM) were obtained from term and preterm pregnancies at the time of cesarean section, either in labor or not in labor. BNP was measured in term and preterm FM, in culture cells, and conditioned media. We found BNP (but not ANP or CNP) inhibited contractions of preterm, but not term, human myometrium. BNP (both protein and mRNA) was detected in all tissues, conditioned media and cultured cells. BNP was higher in samples from preterm women not in labor compared to those at term not in labor. BNP concentrations were significantly reduced in women in spontaneous preterm labor. We conclude that locally produced BNP may be involved in generating myometrial quiescence during pregnancy. Further, a premature decrease of BNP production may cause preterm labor.
dc.fuente.origenWOS
dc.identifier.doi10.1177/1933719108324137
dc.identifier.eissn1933-7205
dc.identifier.issn1933-7191
dc.identifier.urihttps://doi.org/10.1177/1933719108324137
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95731
dc.identifier.wosidWOS:000262572000004
dc.issue.numero1
dc.language.isoen
dc.pagina.final42
dc.pagina.inicio32
dc.revistaReproductive sciences
dc.rightsacceso restringido
dc.subjectBrain natriuretic peptide
dc.subjectchorion
dc.subjectamnion
dc.subjectmyometrial quiescence
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleBrain Natriuretic Peptide (BNP) Produced by the Human Chorioamnion May Mediate Pregnancy Myometrial Quiescence
dc.typeartículo
dc.volumen16
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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