Scavenger receptor class B type I (SR-BI) and high-density lipoprotein metabolism: Recent lessons from genetically manipulated mice
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Date
2000
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BIOSCIENCE EDIPRINT INC
Abstract
The scavenger receptor BI is a cell surface lipoprotein receptor for selective high-density lipoprotein (HDL) cholesterol uptake in the liver and steroidogenic tissues. Studies of genetically manipulated strains of mice have revealed that SR-BI plays a key role in regulating HDL metabolism, cholesterol transport to steroidogenic tissues and bile cholesterol secretion. Furthermore, SR-BI protects against the development of atherosclerosis and is required for normal female fertility: If SR-BI has similar functions in lipoprotein metabolism and atherosclerosis in humans, it may represent a new target for the prevention and/or treatment of atherosclerotic cardiovascular disease.
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Keywords
APOPROTEIN-A-I, DIETARY-CHOLESTEROL, TARGETED MUTATION, APOLIPOPROTEIN-E, SELECTIVE UPTAKE, TRANSGENIC MICE, ADRENAL-CELLS, HUMAN HOMOLOG, HDL, RAT