Association of Remote Hypertension in Pregnancy With Coronary Artery Disease A Case-Control Study

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dc.contributor.authorValdes, Gloria
dc.contributor.authorQuezada, Felipe
dc.contributor.authorMarchant, Eugenio
dc.contributor.authorvon Schultzendorff, Astrid
dc.contributor.authorMoran, Sergio
dc.contributor.authorPadilla, Oslando
dc.contributor.authorMartinez, Alejandro
dc.date.accessioned2024-01-10T12:04:22Z
dc.date.available2024-01-10T12:04:22Z
dc.date.issued2009
dc.description.abstractBecause hypertensive pregnancies have been associated with increased cardiovascular disease, we aimed to identify whether angiographically characterized coronary artery disease differed in women with previous normotensive pregnancies or hypertensive pregnancies (HPs). The study group included 217 parous women, aged 60.9 +/- 9.2 (SD) years, who required coronary angiography between January 2006 and December 2007, 36.8 +/- 9.9 and 28.8 +/- 10.5 years after their first and last pregnancy, respectively; 146 had normotensive pregnancies and 71 had >= 1 HP, according to a questionnaire including reproductive history and cardiovascular risks. Body mass index, smoking, and frequency of diabetes were similar in both groups. Chronic hypertension (93% versus 78%; P=0.007), hyperlipidemia (82% versus 69%; P=0.049), and premature familial cardiovascular disease (42% versus 20%; P=0.001) prevailed in HPs. Participants with HPs were younger (58.9 +/- 8.3 versus 61.9 +/- 9.6 years; P=0.025) than participants with normotensive pregnancies. Although 49% of all participants had hemodynamically significant coronary artery disease (>= 70% stenosis), no differences were observed between groups in the number of stenotic arteries; however, their number increased by 28% and 22% over a 10-year period in HPs and normotensive pregnancies, respectively (P=0.034). Multivariate analysis showed that HPs had a nonsignificant risk of having coronary artery disease (odds ratio: 1.21; 95% CI: 0.64 to 2.28), and being a current smoker (odds ratio: 4.13; 95% CI: 1.85 to 9.25), a diabetic (odds ratio: 2.29; 95% CI: 1.85 to 9.25), or having a family history of premature cardiovascular disease (odds ratio: 2.34; 95% CI: 1.17 to 2.39) significantly increased the risk of coronary artery disease. This study demonstrates that women with HPs have earlier coronary disease, probably related to intermediate cardiovascular risks that have a gestational expression. (Hypertension. 2009; 53: 733-738.)
dc.description.funderFondo Nacional de Ciencia y Tecnolog a (Fondecyt)
dc.description.funderPontificia Universidad Catolica School of Medicine
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/HYPERTENSIONAHA.108.127068
dc.identifier.eissn1524-4563
dc.identifier.issn0194-911X
dc.identifier.pubmedidMEDLINE:19204177
dc.identifier.urihttps://doi.org/10.1161/HYPERTENSIONAHA.108.127068
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75778
dc.identifier.wosidWOS:000264341400029
dc.information.autorucMedicina;Marchant E;S/I;98298
dc.information.autorucMedicina;Martinez A ;S/I;1003862
dc.information.autorucMedicina;Moran S ;S/I;98562
dc.information.autorucMedicina;Padilla O;S/I;102063
dc.information.autorucMedicina;Quezada F ;S/I;132761
dc.information.autorucMedicina;Valdes G ;S/I;98654
dc.issue.numero4
dc.language.isoen
dc.nota.accesoSin adjunto
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaHYPERTENSION
dc.rightsregistro bibliográfico
dc.subjecthypertension in pregnancy
dc.subjectpreeclampsia
dc.subjectcoronary artery disease
dc.subjectcardiovascular risks
dc.subjectcoronary angiography
dc.subjectISCHEMIC-HEART-DISEASE
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectRISK-FACTORS
dc.subjectENDOTHELIAL DYSFUNCTION
dc.subjectRETROSPECTIVE COHORT
dc.subjectMATERNAL RECALL
dc.subjectFAMILY-HISTORY
dc.subjectBLOOD-PRESSURE
dc.subjectLATER LIFE
dc.subjectPREECLAMPSIA
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation of Remote Hypertension in Pregnancy With Coronary Artery Disease A Case-Control Study
dc.typeartículo
dc.volumen53
sipa.codpersvinculados98298
sipa.codpersvinculados1003862
sipa.codpersvinculados98562
sipa.codpersvinculados102063
sipa.codpersvinculados132761
sipa.codpersvinculados98654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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