Interleukin-10 Produced by Myeloid-Derived Suppressor Cells Provides Protection to Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 258 by Enhancing Its Clearance in the Airways

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dc.catalogadordfo
dc.contributor.authorPeñaloza Cerda, Hernán F.
dc.contributor.authorNoguera Mijares, Loreani Paola
dc.contributor.authorAhn, D.
dc.contributor.authorVallejos, Omar
dc.contributor.authorCastellanos, Raquel M.
dc.contributor.authorVazquez, Yaneisi
dc.contributor.authorSalazar Echegarai, Francisco Javier
dc.contributor.authorGonzález Carreño, Liliana
dc.contributor.authorSuazo Gálvez, Isidora del Carmen
dc.contributor.authorPardo Roa, Catalina
dc.contributor.authorSalazar, Geraldyne
dc.contributor.authorPrince, Alice
dc.contributor.authorBueno Ramírez, Susan
dc.date.accessioned2024-01-31T12:39:22Z
dc.date.available2024-01-31T12:39:22Z
dc.date.issued2019
dc.description.abstractCarbapenem-resistant Klebsiella pneumoniae sequence type 258 (CRKP-ST258) can cause chronic infections in lungs and airways, with repeated episodes of bacteremia. In this report we addressed whether the recruitment of myeloid cells producing the anti-inflammatory cytokine interleukin-10 (IL-10) modulates the clearance of CKRP-ST258 in the lungs and establishes bacterial persistence. Our data demonstrate that during pneumonia caused by a clinical isolate of CRKP-ST258 (KP35) there is an early recruitment of monocyte-myeloid-derived suppressor cells (M-MDSCs) and neutrophils that actively produce IL-10. However, M-MDSCs were the cells that sustained the production of IL-10 over the time of infection evaluated. Using mice unable to produce IL-10 (IL-10-/-), we observed that the production of this cytokine during the infection caused by KP35 is important to control bacterial burden, to prevent lung damage, to modulate cytokine production, and to improve host survival. Importantly, intranasal transfer of bone marrow-derived M-MDSCs from mice able to produce IL-10 at 1 day prior to infection improved the ability of IL-10-/- mice to clear KP35 in the lungs, decreasing their mortality. Altogether, our data demonstrate that IL-10 produced by M-MDSCs is required for bacterial clearance, reduction of lung tissue damage, and host survival during KP35 pneumonia.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1128/IAI.00665-18
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81092
dc.information.autorucFacultad de Ciencias Biológicas; Peñaloza Cerda, Hernán F.; S/I; 186994
dc.information.autorucFacultad de Ciencias Biológicas; Noguera Mijares, Loreani Paola; S/I; 225123
dc.information.autorucFacultad de Ciencias Biológicas; Vallejos, Omar; S/I; 215421
dc.information.autorucFacultad de Ciencias Biológicas; Vazquez, Yaneisi; S/I; 1025308
dc.information.autorucFacultad de Ciencias Biológicas; Salazar Echegarai, Francisco Javier; S/I; 1011015
dc.information.autorucFacultad de Ciencias Biológicas; González Carreño, Liliana; S/I; 250114
dc.information.autorucFacultad de Ciencias Biológicas; Suazo Gálvez, Isidora del Carmen; S/I; 215403
dc.information.autorucFacultad de Ciencias Biológicas; Pardo Roa, Catalina; 0000-0002-5409-225X; 225251
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaInfection and Immunity
dc.rightsacceso restringido
dc.subjectKlebsiella pneumoniae ST258
dc.subjectInterleukin-10
dc.subjectMonocytic-myeloid-derived suppressor cells
dc.subjectNeutrophils
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.titleInterleukin-10 Produced by Myeloid-Derived Suppressor Cells Provides Protection to Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 258 by Enhancing Its Clearance in the Airways
dc.typeartículo
sipa.codpersvinculados186994
sipa.codpersvinculados225123
sipa.codpersvinculados215421
sipa.codpersvinculados1025308
sipa.codpersvinculados1011015
sipa.codpersvinculados250114
sipa.codpersvinculados215403
sipa.codpersvinculados225251
sipa.codpersvinculados113541
sipa.trazabilidadConveris;20-07-2021
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