Peri-spinal Neurovascular Response Triggered by a Painless Electrical Nerve Stimulation in Patients with Chronic Arterial Hypertension

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dc.contributor.authorAppelgren, Juan Pablo Gonzalez
dc.contributor.authorCaulier-Cisterna, Raul
dc.contributor.authorOyarzun, Juan Esteban
dc.contributor.authorUribe, Sergio
dc.contributor.authorEblen-Zajjur, Antonio
dc.date.accessioned2025-01-20T20:14:39Z
dc.date.available2025-01-20T20:14:39Z
dc.date.issued2023
dc.description.abstractPurposeAlterations of the central nervous system are frequent complications in patients with chronic arterial hypertension (AHT). However, functional spinal cord lesions are not often detected in these patients despite diagnostic advances in neuroimaging and electrophysiology. Recently, a new non-invasive functional near infrared spectroscopy (fNIRS) application was developed for assessment of the peri-spinal neurovascular response (NVR) as a functional test of the spinal cord.MethodsThe continuous wave fNIRS technique was applied to detect changes in O(2)Hb concentration during the peri-spinal NVR triggered by non-noxious electrical stimulation of the median nerve at the wrist, and recorded at cervical and thoracic spinal levels using three different stimulation protocols in subjects with AHT treated with losartan (n = 22; 142.14 +/- 133.9 months of disease) and compared to healthy control subjects (n = 37). The body mass index (BMI) and the median nerve conduction velocity (NCV) were also recorded.ResultsThe NVR of patients with AHT showed a significantly lower amplitude (- 70.4%; cervical), longer rise time (+ 22.2%; cervical), and longer duration (+ 28.0%; thoracic) than the control group (p < 0.01). The stimulus intensity-response in the AHT group was - 53.5%, - 55.9%, and - 63% lower in amplitude than the controls (p < 0.05) for the increasing stimulus intensity steps (5; 7.5 and 10 mA, respectively) at the cervical level. Patients with BMI > 30 showed more intense changes. The median NCV was normal for both groups.ConclusionThese data show, for the first time, the difference in peri-spinal NVR between normal subjects and losartan-treated ATH patients, indicating the potential of a non-invasive fNIRS technique to find sensory functional abnormalities of the spinal cord in these patients.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s40846-023-00789-w
dc.identifier.eissn2199-4757
dc.identifier.issn1609-0985
dc.identifier.urihttps://doi.org/10.1007/s40846-023-00789-w
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92211
dc.identifier.wosidWOS:000984759100001
dc.issue.numero3
dc.language.isoen
dc.pagina.final311
dc.pagina.inicio303
dc.revistaJournal of medical and biological engineering
dc.rightsacceso restringido
dc.subjectNear infrared spectroscopy
dc.subjectSpinal neurovascular response
dc.subjectNon-invasive method
dc.subjectSpinal neuronal activity
dc.subjectNeurovascular coupling
dc.subjectArterial hypertension
dc.subjectLosartan
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePeri-spinal Neurovascular Response Triggered by a Painless Electrical Nerve Stimulation in Patients with Chronic Arterial Hypertension
dc.typeartículo
dc.volumen43
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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