Prevalence of microcephaly: The Latin American Network of Congenital Malformations 2010-2017

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dc.article.numbere001235
dc.catalogadorgrr
dc.contributor.authorMorris, J.
dc.contributor.authorLimb, E.
dc.contributor.authorOrioli, I.M.
dc.contributor.authorBenavides-Lara, A.
dc.contributor.authorDe La Paz Barboza-Arguello, M.
dc.contributor.authorTapia, M.A.C.
dc.contributor.authorDe Franca, G.V.A.
dc.contributor.authorGroisman, B.
dc.contributor.authorHolguin, J.
dc.contributor.authorHurtado-Villa, P.M.
dc.contributor.authorIbarra Ramirez, M.
dc.contributor.authorMellado Sagredo, Cecilia Ximena Del Carmen
dc.contributor.authorPardo, R.
dc.contributor.authorPastora Bucardo D.M.
dc.contributor.authorRodriguez, C.
dc.contributor.authorZarante, I.
dc.contributor.authorDolk, H.
dc.date.accessioned2024-01-16T16:20:33Z
dc.date.available2024-01-16T16:20:33Z
dc.date.issued2021
dc.description.abstractObjective: The Latin American Network of Congenital Malformations: ReLAMC was established in 2017 to provide accurate congenital anomaly surveillance. This study used data from ReLAMC registries to quantify the prevalence of microcephaly from 2010 to 2017 (before, during and after the Zika virus epidemic). Design Nine ReLAMC congenital anomaly registries provided case-level data or aggregate data for any live births, still births or terminations of pregnancy with microcephaly. Births to pregnant women infected with Zika virus first occurred in Brazil in 2015, and in the remaining registry areas in 2016 with the exception of Chile that did not experience Zika virus. Therefore the prevalence of microcephaly for 2010-2014 and individual years 2015, 2016 and 2017 was estimated using multilevel random effect Poisson models. Clinical classification and characteristics of the cases were compared pre and post Zika for all centres providing individual case-level data. Results The prevalence of microcephaly for all registries excluding Brazil was 2.3 per 10 000 (95% CI 2.0 to 2.6) for 2010-2014 rising to 5.4 (95% CI 4.8 to 6.0) in 2016 and 5.9 (95% CI 5.3 to 6.6) in 2017. Brazil had a prevalence of 0.6 per 10 000 (95% CI 0.5 to 0.6) in 2010-2014, rising to 5.8 (95% CI 5.6 to 6.1) in 2015, 8.0 (95% CI 7.6 to 8.3) in 2016 and then falling in 2017. Only 29 out of 687 cases of microcephaly were reported as congenital Zika syndrome in countries excluding Brazil. Conclusions The prevalence of microcephaly was influenced both by Zika causing congenital Zika syndrome and by increased reporting awareness.
dc.fechaingreso.objetodigital2024-01-16
dc.format.extent8 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1136/bmjpo-2021-001235
dc.identifier.eissn23999772
dc.identifier.issn2399-9772
dc.identifier.pubmedid34901471
dc.identifier.scopusidSCOPUS_ID:85120572100
dc.identifier.urihttp://bmjpaedsopen.bmj.com/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80491
dc.information.autorucEscuela de Medicina; Mellado Sagredo, Cecilia Ximena Del Carmen; 0000-0002-6032-4651; 1002671
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherBMJ Publishing Group
dc.revistaBMJ Paediatrics Open
dc.rightsacceso abierto
dc.subjectData collection
dc.subjectEpidemiology
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePrevalence of microcephaly: The Latin American Network of Congenital Malformations 2010-2017
dc.typeartículo
dc.volumen5
sipa.codpersvinculados1002671
sipa.trazabilidadORCID;2024-01-15
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