Diabetogenic transferrin damages podocytes in early human diabetic nephropathy

Simple item page
dc.contributor.authorGonzalez, S
dc.contributor.authorVargas, L
dc.date.accessioned2024-01-10T12:38:20Z
dc.date.available2024-01-10T12:38:20Z
dc.date.issued2001
dc.description.abstractThe exact mechanisms by which growth hormone (GH) damages the kidney inducing diabetic nephropathy has not yet been elucidated. Recently, it has been shown that transferrin has the same diabetogenic effects of GH, being its mediator. Transferrin was studied using immunohistochemistry and immunoelectron microscopy in cases of early diabetic nephropathy, and in controls. Transferrin was only found in diabetic cases in podocytes and Bowman's capsule cells, but also in the tubular cells of both diabetic and non-diabetic controls. Immune-electron microscopy for the presence of transferrin showed positive signals in the cytoplasm of diabetic podocytes, but not in pedicels. This selective deposition was associated with signs of organelle and cytoskeleton damage. On the basis of previous evidence and present glomerular findings, these results suggest an indirect diabetogenic effect on the kidney by GH mediated through transferrin.
dc.fechaingreso.objetodigital2024-04-25
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1055/s-2001-12406
dc.identifier.eissn1439-4286
dc.identifier.issn0018-5043
dc.identifier.pubmedidMEDLINE:11294498
dc.identifier.urihttps://doi.org/10.1055/s-2001-12406
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77028
dc.identifier.wosidWOS:000167827000005
dc.information.autorucMedicina;González S;S/I;99856
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final88
dc.pagina.inicio84
dc.publisherGEORG THIEME VERLAG KG
dc.revistaHORMONE AND METABOLIC RESEARCH
dc.rightsacceso restringido
dc.subjectgrowth hormone
dc.subjecttransferrin
dc.subjectpodocyte
dc.subjectdiabetic nephropathy
dc.subjectMICE
dc.subjectPROGRESSION
dc.subjectRECEPTORS
dc.subjectALBUMIN
dc.subjectGLUCOSE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDiabetogenic transferrin damages podocytes in early human diabetic nephropathy
dc.typeartículo
dc.volumen33
sipa.codpersvinculados99856
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-04-25. Diabetogenic transferrin damages podocytes in early human diabetic nephropathy.pdf
Size:
2.6 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas