Motion-corrected whole-heart PET-MR for the simultaneous visualisation of coronary artery integrity and myocardial viability: an initial clinical validation

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dc.catalogadorgjm
dc.contributor.authorMuñoz, Camila
dc.contributor.authorKunze, Karl P.
dc.contributor.authorNeji, Radhouene
dc.contributor.authorVitadello, Teresa
dc.contributor.authorRischpler, Christoph
dc.contributor.authorBotnar, René Michael
dc.contributor.authorNekolla, Stephan G.
dc.contributor.authorPrieto Vásquez, Claudia
dc.date.accessioned2023-05-19T20:50:27Z
dc.date.available2023-05-19T20:50:27Z
dc.date.issued2018
dc.description.abstractPurpose: Cardiac PET-MR has shown potential for the comprehensive assessment of coronary heart disease. However, image degradation due to physiological motion remains a challenge that could hinder the adoption of this technology in clinical practice. The purpose of this study was to validate a recently proposed respiratory motion-corrected PET-MR framework for the simultaneous visualisation of myocardial viability (18F-FDG PET) and coronary artery anatomy (coronary MR angiography, CMRA) in patients with chronic total occlusion (CTO). Methods: A cohort of 14 patients was scanned with the proposed PET-CMRA framework. PET and CMRA images were reconstructed with and without the proposed motion correction approach for comparison purposes. Metrics of image quality including visible vessel length and sharpness were obtained for CMRA for both the right and left anterior descending coronary arteries (RCA, LAD), and relative increase in 18F-FDG PET signal after motion correction for standard 17-segment polar maps was computed. Resulting coronary anatomy by CMRA and myocardial integrity by PET were visually compared against X-ray angiography and conventional Late Gadolinium Enhancement (LGE) MRI, respectively. Results: Motion correction increased CMRA visible vessel length by 49.9% and 32.6% (RCA, LAD) and vessel sharpness by 12.3% and 18.9% (RCA, LAD) on average compared to uncorrected images. Coronary lumen delineation on motion-corrected CMRA images was in good agreement with X-ray angiography findings. For PET, motion correction resulted in an average 8% increase in 18F-FDG signal in the inferior and inferolateral segments of the myocardial wall. An improved delineation of myocardial viability defects and reduced noise in the 18F-FDG PET images was observed, improving correspondence to subendocardial LGE-MRI findings compared to uncorrected images. Conclusion: The feasibility of the PET-CMRA framework for simultaneous cardiac PET-MR imaging in a short and predictable scan time (~11 min) has been demonstrated in 14 patients with CTO. Motion correction increased visible length and sharpness of the coronary arteries by CMRA, and improved delineation of the myocardium by 18F-FDG PET, resulting in good agreement with X-ray angiography and LGE-MRI.
dc.fechaingreso.objetodigital2023-07-14
dc.fuente.origenORCID
dc.identifier.doi10.1007/s00259-018-4047-7
dc.identifier.eissn1619-7089
dc.identifier.issn1619-7070
dc.identifier.urihttps://doi.org/10.1007/s00259-018-4047-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/70263
dc.identifier.wosidWOS:000443332200014
dc.information.autorucEscuela de Ingeniería; Botnar, René Michael; 0000-0002-9447-4367; 1015313
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia; 0000-0003-4602-2523; 14195
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final1986
dc.pagina.inicio1975
dc.revistaEuropean Journal of Nuclear Medicine and Molecular Imaging
dc.rightsacceso abierto
dc.subjectCardiac PET-MRes_ES
dc.subjectMotion correctiones_ES
dc.subjectCoronary artery diseasees_ES
dc.subjectCoronary MR angiographyes_ES
dc.subject.ddc620
dc.subject.deweyIngenieríaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMotion-corrected whole-heart PET-MR for the simultaneous visualisation of coronary artery integrity and myocardial viability: an initial clinical validationes_ES
dc.typeartículo
dc.volumen45
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
sipa.trazabilidadORCID;14-07-2023
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