Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus - An international meta-analysis

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dc.contributor.authorKarassa, FB
dc.contributor.authorAfeltra, A
dc.contributor.authorAmbrozic, A
dc.contributor.authorChang, DM
dc.contributor.authorDe Keyser, F
dc.contributor.authorDoria, A
dc.contributor.authorGaleazzi, M
dc.contributor.authorHirohata, S
dc.contributor.authorHoffman, IEA
dc.contributor.authorInanc, M
dc.contributor.authorMassardo, L
dc.contributor.authorMathieu, A
dc.contributor.authorMok, CC
dc.contributor.authorMorozzi, G
dc.contributor.authorSanna, G
dc.contributor.authorSpindler, AJ
dc.contributor.authorTzioufas, AG
dc.contributor.authorYoshio, T
dc.contributor.authorIoannidis, JPA
dc.date.accessioned2024-01-10T13:45:34Z
dc.date.available2024-01-10T13:45:34Z
dc.date.issued2006
dc.description.abstractObjective. To quantitatively evaluate the diagnostic accuracy of antibodies to ribosomal P proteins (anti-P) for neuropsychiatric systemic lupus erythematosus (NPSLE) in general, for psychosis, mood disorder, or both, and for other diffuse manifestations.
dc.description.abstractMethods. This international meta-analysis combined standardized data from 1,537 lupus patients contributed by 14 research teams. Weighted estimation of sensitivity and specificity with fixed-effects and random-effects models, as well as summary receiver operating characteristic (SROC) curve analysis, was used to summarize test performance. The robustness of the overall estimates was examined in sensitivity analyses that included additional studies published up to November 1, 2004 in the Medline, EMBase, and Cochrane databases.
dc.description.abstractResults. Combining the data from the 14 teams, the weighted sensitivity and specificity estimates for the diagnosis of NPSLE were 26% (95% confidence interval [95% CI] 15-42%) and 80% (95% CI 74-85%), respectively. For psychosis, mood disorder, or both, the sensitivity and specificity were 27% (95% CI 14-47%) and 80% (95% CI 74-85%), respectively. For other diffuse manifestations, the sensitivity was 24% (95% CI 12-42%), and the specificity was 80% (95% CI 73-85%). The proportion of patients with anti-P antibodies did not vary markedly across different presentations of NPSLE. Between-study heterogeneity was substantial, but the SROC curves were consistent with the weighted estimates. In further analyses that included another 24 published studies, only the sensitivity for psychosis and/or mood disorder was slightly improved, but it was still suboptimal (42% [95% Cl 30-53%]); the specificity remained essentially the same (81% [95% Cl 76-85%]).
dc.description.abstractConclusion. Anti-P antibody testing has limited diagnostic value for NPSLE, and it is not helpful in differentiating among various disease phenotypes.
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/art.21539
dc.identifier.eissn1529-0131
dc.identifier.issn0004-3591
dc.identifier.pubmedidMEDLINE:16385548
dc.identifier.urihttps://doi.org/10.1002/art.21539
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79050
dc.identifier.wosidWOS:000234605200038
dc.information.autorucMedicina;Massardo L;S/I;100068
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final324
dc.pagina.inicio312
dc.publisherWILEY
dc.revistaARTHRITIS AND RHEUMATISM
dc.rightsacceso restringido
dc.subjectPSYCHIATRIC MANIFESTATIONS
dc.subjectRHEUMATIC-DISEASES
dc.subjectRENAL-DISEASE
dc.subjectAUTOANTIBODIES
dc.subjectASSOCIATION
dc.subjectGUIDELINES
dc.subjectPSYCHOSIS
dc.subjectCRITERIA
dc.subjectCLASSIFICATION
dc.subjectPOPULATIONS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAccuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus - An international meta-analysis
dc.typeartículo
dc.volumen54
sipa.codpersvinculados100068
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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