Analysis of the complementary determining region III of the immunoglobulin heavy chain locus in acute lymphoblastic leukemia in Chilean children

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dc.contributor.authorBarriga, FJ
dc.contributor.authorRisueno, C
dc.contributor.authorPatillo, JC
dc.contributor.authorAndrade, W
dc.contributor.authorCabrera, ME
dc.contributor.authorBeressi, V
dc.contributor.authorDelBorgo, P
dc.contributor.authorSalgado, C
dc.contributor.authorBecker, A
dc.contributor.authorCampbell, M
dc.contributor.authorBertin, P
dc.date.accessioned2025-01-21T01:33:43Z
dc.date.available2025-01-21T01:33:43Z
dc.date.issued1996
dc.description.abstractWe have analyzed the sequence of 40 VDJ rearrangements of the immunoglobulin heavy chain gene locus on 32 unselected children from Chile with precursor B cell ALL at diagnosis. Rearrangements were derived by PCR with VH gene family-specific primers and sequenced directly. The number of VDJ rearrangements, and the pattern of VH, DH and JH gene usage was identical to the one reported by groups from developed countries. CDR3 regions represented an unbiased repertoire; VH to JH joinings were in frame in 36% of cases. Absent N nucleotides in the DJ border, suggestive of fetal origin of ALL, were seen in 9/40 rearrangements but they did not correlate with younger age. More than one rearrangement was sequenced in six patients, representing independent events with no signs of clonal evolution. One patient was analyzed at first bone marrow relapse showing persistence of one rearrangement and evolution of a second one which conserved the DJ border. The subset of B cell precursors which suffer malignant transformation to ALL appear to be common in different parts of the world.
dc.fuente.origenWOS
dc.identifier.issn0887-6924
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97462
dc.identifier.wosidWOS:A1996VQ58100009
dc.issue.numero11
dc.language.isoen
dc.pagina.final1723
dc.pagina.inicio1719
dc.revistaLeukemia
dc.rightsacceso restringido
dc.subjectALL
dc.subjectCDR3
dc.subjectimmunoglobulin heavy chain gene
dc.subjectIgH
dc.subjectChile
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAnalysis of the complementary determining region III of the immunoglobulin heavy chain locus in acute lymphoblastic leukemia in Chilean children
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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