Short bowel syndrome related intestinal failure outcomes in Latin America: Insights from the RESTORE Registry

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dc.contributor.authorRumbo, Carolina
dc.contributor.authorSolar, Hector
dc.contributor.authorOrtega, Mariana
dc.contributor.authorBusoni, Veronica
dc.contributor.authorde Barrio, Silvia
dc.contributor.authorMartinuzzi, Andres
dc.contributor.authorMartinez, Maria Ines
dc.contributor.authorPlata, Clara
dc.contributor.authorDonnadio, Luciana
dc.contributor.authorZuniga, Aurora Serralde
dc.contributor.authorSaure, Carola
dc.contributor.authorPerez, Claudia
dc.contributor.authorTanzi, Maria Noel
dc.contributor.authorConsuelo, Alejandra
dc.contributor.authorBecerra, Andres
dc.contributor.authorManzur, Alejandra
dc.contributor.authorMoya, Diego Arenas
dc.contributor.authorRudi, Lorena
dc.contributor.authorMoreira, Eduardo
dc.contributor.authorBuncuga, Martin
dc.contributor.authorHodgson, Maria Isabel
dc.contributor.authorClaria, Rodrigo Sanchez
dc.contributor.authorFernandez, Adriana
dc.contributor.authorGondolesi, Gabriel
dc.date.accessioned2025-01-20T16:07:25Z
dc.date.available2025-01-20T16:07:25Z
dc.date.issued2024
dc.description.abstractBackgroundShort bowel syndrome is considered a low prevalence disease. The scant information available about intestinal failure in Latin America was the driving force to expand this registry.MethodsA prospective, multicenter observational registry was created for patients with chronic intestinal failure short bowel at specialized centers in Latin America. Demographics, clinical characteristics, nutrition assessment, parenteral nutrition management, intestinal rehabilitation, related complications, clinical outcome, and survival were analyzed.ResultsFrom May 2020 to July 2023, 167 patients (115 adults, 52 children) from 20 centers were enrolled. For the adults, the mean age was 37.2 +/- 18 years, 48% were female, and the mean follow-up was 22.6 +/- 18.3 months. The main etiology was surgical resections (postsurgical complications: 37%; ischemia: 25%); the mean intestinal length was 73 +/- 55 cm. The complications were as follows: infections: 0.4/1000 catheter-days; thrombosis: 0.24/1000 catheter-days; liver disease: 2.6%. The outcomes were as follows: 28% were rehabilitated, 15% died, 9.6% were lost to follow-up, 0.9% underwent transplant, and 45.6% continued follow-up. For the children, the mean age 48 +/- 52 months, 48% were female, 52% were premature. The mean follow-up was 17.2 +/- 5.6 months; the mean remaining intestinal length was 38 +/- 45 cm. The leading etiologies were atresia (25%), NEC (23%), and gastroschisis (21%). The complication were as follows: infections: 2/1000 catheter-days; thrombosis: 2.22/1000 catheter-day; 25% developed liver disease. The outcomes were as follows: 7.7% died, 3.8% were rehabilitated, and 88.5% continued follow-up.ConclusionThe RESTORE amendment served as a registry and educational tool for the participating teams. The aspiration is to objectively show current aspects of intestinal failure in the region and carry them to international standards. Including all Latin American countries and etiologies of chronic intestinal failure besides short gut would serve to complete this registry.
dc.fuente.origenWOS
dc.identifier.doi10.1002/jpen.2693
dc.identifier.eissn1941-2444
dc.identifier.issn0148-6071
dc.identifier.urihttps://doi.org/10.1002/jpen.2693
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90002
dc.identifier.wosidWOS:001326155700001
dc.issue.numero8
dc.language.isoen
dc.pagina.final964
dc.pagina.inicio956
dc.revistaJournal of parenteral and enteral nutrition
dc.rightsacceso restringido
dc.subjectintestinal failure
dc.subjectLatin America
dc.subjectparenteral nutrition
dc.subjectregistry
dc.subjectshort bowel syndrome
dc.subject.ods02 Zero Hunger
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa02 Hambre cero
dc.subject.odspa03 Salud y bienestar
dc.titleShort bowel syndrome related intestinal failure outcomes in Latin America: Insights from the RESTORE Registry
dc.typeartículo
dc.volumen48
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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