Efficacy of Oral Corticosteroids in the Treatment of Acute Wheezing Episodes in Asthmatic Preschoolers : Systematic Review With Meta-Analysis

Simple item page
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorBeckhaus, Andrea A.
dc.contributor.authorForno, Erick
dc.date.accessioned2020-08-07T13:54:34Z
dc.date.available2020-08-07T13:54:34Z
dc.date.issued2016
dc.description.abstractRationale: Systemic corticosteroids (SCS) are used for treat preschoolers with acute asthma or wheezing exacerbations, with conflicting results. Objective: To evaluate the effectiveness of oral corticosteroids (OCS) compared to placebo in preschoolers presenting with acute asthma/wheezing exacerbations. Methods: Five electronic databases were searched for all placebo-controlled, randomized clinical trials of OCS in children <6 years of age presenting with recurrent wheezing/asthma exacerbations of any severity. Primary outcomes were hospitalizations, unscheduled emergency department (ED) visits in following month, need of additional OCS courses, and length of stay (ED or hospital). Results: Eleven studies met inclusion criteria (n = 1,733); four were conducted on an outpatient basis, five in inpatients, and two in the ED. Significant heterogeneity was found when pooling all studies, and thus analysis was stratified by trial setting. Among the outpatient studies, children who received OCS had a higher hospitalization rate (RR: 2.15 [95%CI = 1.08–4.29], I2 = 0%) compared to those to received placebo. Among the ED studies, children who received OCS had a lower risk of hospitalization (RR: 0.58 [0.37–0.92], I2 = 0%). Among the inpatient studies, children who received OCS needed fewer additional OCS courses than those on placebo (RR: 0.57 [0.40–0.81], I2 = 0%). Conclusions: Treatment with OCS in the ED or hospital may be beneficial in toddlers and preschoolers with frequent asthma/wheezing exacerbations. However, more studies are needed before OCS can be broadly recommended for this age group. Future trials should be carefully designed to avoid bias and according to our findings regarding administration setting.
dc.format.extent9 páginas
dc.fuente.origenConveris
dc.identifier.doi10.1002/ppul.23429
dc.identifier.issn8755-6863
dc.identifier.issn1099-0496
dc.identifier.urihttps://doi.org/10.1002/ppul.23429
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/38439
dc.information.autorucEscuela de medicina ; Castro Rodríguez, José Antonio ; 0000-0002-0708-4281 ; 113247
dc.issue.numeroNo. 8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final876
dc.pagina.inicio868
dc.relation.isformatofPediatric Pulmonology, vol. 51, no. 8 (ago. 2016)., pp. 868-876.
dc.revistaPediatric Pulmonologyes_ES
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherAsma en niñoses_ES
dc.subject.otherAsma - Investigacioneses_ES
dc.subject.otherAsma - Terapiaes_ES
dc.titleEfficacy of Oral Corticosteroids in the Treatment of Acute Wheezing Episodes in Asthmatic Preschoolers : Systematic Review With Meta-Analysises_ES
dc.typeartículo
dc.volumenVol. 51
sipa.codpersvinculados113247
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ppul.23429.pdf
Size:
1.34 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas