ACUTE EFFECT OF SYSTEMIC VERSUS INTRACORONARY DIPYRIDAMOLE ON CORONARY CIRCULATION

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dc.contributor.authorMARCHANT, E
dc.contributor.authorPICHARD, A
dc.contributor.authorRODRIGUEZ, JA
dc.contributor.authorCASANEGRA, P
dc.date.accessioned2025-01-23T19:26:26Z
dc.date.available2025-01-23T19:26:26Z
dc.date.issued1986
dc.description.abstractDipyridamole has been proposed as an ideal agent to evaluate coronary vascular reserve because it produces selective coronary vasodilation without systemic hemodynamic effect. The actions of intracoronary (IC) and intravenous (IV) dipyridamole on coronary blood flow and systemic hemodynamics were compared in 15 patients with chest pain syndrome and normal coronary arteries. They received IC dipyridamole, followed 10 minutes later by 0.5 mg/kg of IV dipridamole. IC dipyridamole produced a 73% increase in coronary sinus flow without hemodynamic changes, except for a slight increase in pulmonary systolic and diastolic pressures. IV dipyridamole administration produced an additional 88% increase in coronary sinus flow, reaching 172% over baseline; it was also associated with a significant (p < 0.01) increase in heart rate (78 .+-. 14 vs 102 .+-. 19 beats/min), cardiac index (4 .+-. 0.7 vs 6.3 .+-. 1.7 liters/min/m2), and pulmonary artery systolic (27 .+-. 5 vs 34 .+-. 7 mm Hg) and diastolic pressure (12 .+-. 4 vs 19 .+-. 7 mm Hg). These data suggest that the coronary vasodilatory effect seen after IV dipyridamole administration is related to mechanisms other than direct coronary vasodilation.
dc.fuente.origenWOS
dc.identifier.eissn1879-1913
dc.identifier.issn0002-9149
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99609
dc.identifier.wosidWOS:A1986C604500034
dc.issue.numero15
dc.language.isoen
dc.pagina.final1404
dc.pagina.inicio1401
dc.revistaAmerican journal of cardiology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleACUTE EFFECT OF SYSTEMIC VERSUS INTRACORONARY DIPYRIDAMOLE ON CORONARY CIRCULATION
dc.typeartículo
dc.volumen57
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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