Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission

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dc.catalogadorjwg
dc.contributor.authorMira, Rodrigo G.
dc.contributor.authorLira, Matias
dc.contributor.authorCerpa Nebott Waldo Francisco
dc.contributor.authorTapia-Rojas, Cheril
dc.contributor.authorRebolledo, Daniela
dc.contributor.authorQuintanilla, Rodrigo A.
dc.date.accessioned2024-01-26T14:52:36Z
dc.date.available2024-01-26T14:52:36Z
dc.date.issued2020
dc.description.abstract© Copyright © 2020 Mira, Lira, Tapia-Rojas, Rebolledo, Quintanilla and Cerpa. Problematic alcohol drinking and alcohol dependence are an increasing health problem worldwide. Alcohol abuse is responsible for approximately 5% of the total deaths in the world, but addictive consumption of it has a substantial impact on neurological and memory disabilities throughout the population. One of the better-studied brain areas involved in cognitive functions is the hippocampus, which is also an essential brain region targeted by ethanol. Accumulated evidence in several rodent models has shown that ethanol treatment produces cognitive impairment in hippocampal-dependent tasks. These adverse effects may be related to the fact that ethanol impairs the cellular and synaptic plasticity mechanisms, including adverse changes in neuronal morphology, spine architecture, neuronal communication, and finally an increase in neuronal death. There is evidence that the damage that occurs in the different brain structures is varied according to the stage of development during which the subjects are exposed to ethanol, and even much earlier exposure to it would cause damage in the adult stage. Studies on the cellular and cognitive deficiencies produced by alcohol in the brain are needed in order to search for new strategies to reduce alcohol neuronal toxicity and to understand its consequences on memory and cognitive performance with emphasis on the crucial stages of development, including prenatal events to adulthood.
dc.description.funderCenter for Excellence in Science and Technology
dc.description.funderSociedad Química y Minera de Chile
dc.description.funderBMBF
dc.description.funderFondo Nacional de Desarrollo Científico y Tecnológico
dc.fechaingreso.objetodigital2024-12-19
dc.fuente.origenScopus
dc.identifier.doi10.3389/fnbeh.2019.00288
dc.identifier.issn16625153
dc.identifier.pubmedidMEDLINE:32038190
dc.identifier.scopusidSCOPUS_ID:85079173543
dc.identifier.urihttps://www.frontiersin.org/journals/behavioral-neuroscience
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80984
dc.identifier.wosidWOS:000511940900001
dc.information.autorucFacultad de Ciencias Biológicas; Cerpa Nebott Waldo Francisco; 0000-0001-7344-0144; 16584
dc.issue.numero288
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherFrontiers Media S.A.
dc.revistaFrontiers in Behavioral Neuroscience
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleEffect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission
dc.typeartículo
dc.volumen13
sipa.codpersvinculados16584
sipa.trazabilidadORCID;2024-01-15
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