Effects of Long-Term Nitric Oxide Synthesis Inhibition on Plasma Volume Expansion and Fetal Growth in the Pregnant Rat

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dc.contributor.authorSalas, Sofía P.
dc.contributor.authorAltermatt, Fernando
dc.contributor.authorCampos, Mauricio
dc.contributor.authorGiacaman, Andrea
dc.contributor.authorRosso R., Pedro Pablo
dc.date.accessioned2024-08-22T21:51:38Z
dc.date.available2024-08-22T21:51:38Z
dc.date.issued1995
dc.description.abstractWe conducted the present study to investigate whether the vasodilator nitric oxide plays a role in plasma volume homeostasis during pregnancy. Pregnant Sprague-Dawley rats were randomly assigned to a control group (n = 18) or to groups receiving 0.69 mmol/L (n = 11) or 1.7 mmol/L (n = 14) N-omega-nitro-L-arginine, a competitive inhibitor of nitric oxide synthetase, from gestational days 7 through 21. On day 20 systolic pressure was measured. On day 21 blood samples were taken for plasma volume, hematocrit, and hormonal measurements. Fetal and placental weights also were determined. Systolic pressure was significantly higher in experimental rats (101+/-6 and 115+/-6 mm Hg in the 0.69 and 1.7 mmol/L groups, respectively) than in controls (79.7+/-7.5 mm Hg), and plasma volume was lower (18.4+/-1.1 and 17.1+/-0.5 mL) than in controls (21.5+/-0.8 mL). Both experimental groups had increased hematocrit levels. Plasma renin activity was significantly lower in the experimental groups (11.5+/-3 and 7.2+/-1.5 ng angiotensin I/mL per hour) than in controls (21.9+/-2.7 ng angiotensin I/mL per hour); however, no changes were observed in aldosterone levels. Experimental groups had lower fetal weight (4.6+/-0.1 and 5.1+/-0.1 g) than controls (5.5+/-0.1 g). In addition, fetal hindlimb hypoplasia was observed in the experimental groups. In conclusion, the present data indicate that long-term N-omega-nitro-L-arginine administration to pregnant rats leads to increased blood pressure, reduced plasma volume expansion, lower plasma renin activity, and fetal growth retardation. These results suggest that nitric oxide may play an important role in maternal systemic vasodilatation and indirectly in plasma volume homeostasis and fetal growth.
dc.fuente.origenHistorial Académico
dc.identifier.doi10.1161/01.HYP.26.6.1019
dc.identifier.issn0194-911X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87637
dc.identifier.wosidWOS:A1995TK02300002
dc.information.autorucEscuela de Medicina; Altermatt, Fernando; 0000-0002-0464-8643; 7381
dc.information.autorucEscuela de Medicina; Rosso R., Pedro Pablo; S/I; 98560
dc.issue.numero6
dc.language.isoen
dc.pagina.final1023
dc.pagina.inicio1019
dc.revistaHypertension
dc.rightsacceso restringido
dc.subjectPregnancy
dc.subjectNitric oxide
dc.subjectAldosterone
dc.subjectRenin
dc.subjectFetal growth retardation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of Long-Term Nitric Oxide Synthesis Inhibition on Plasma Volume Expansion and Fetal Growth in the Pregnant Rat
dc.typeartículo
dc.volumen26
sipa.codpersvinculados7381
sipa.codpersvinculados98560
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID;2024-08-19
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