Tobacco Smoke Mediated Induction of Sinonasal Microbial Biofilms

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dc.contributor.authorGoldstein Daruech, Natalia
dc.contributor.authorCope, Emily K.
dc.contributor.authorZhao, Ke Qing
dc.contributor.authorVukovic, Katarina
dc.contributor.authorKofonow, Jennifer M.
dc.contributor.authorDoghramji, Laurel
dc.contributor.authorGonzalez, Bernardo
dc.contributor.authorChiu, Alexander G.
dc.contributor.authorKennedy, David W.
dc.contributor.authorPalmer, James N.
dc.contributor.authorLeid, Jeffery G.
dc.contributor.authorKreindler, James L.
dc.contributor.authorCohen, Noam A.
dc.date.accessioned2024-01-10T13:43:58Z
dc.date.available2024-01-10T13:43:58Z
dc.date.issued2011
dc.description.abstractCigarette smokers and those exposed to second hand smoke are more susceptible to life threatening infection than nonsmokers. While much is known about the devastating effect tobacco exposure has on the human body, less is known about the effect of tobacco smoke on the commensal and commonly found pathogenic bacteria of the human respiratory tract, or human respiratory tract microbiome. Chronic rhinosinusitis (CRS) is a common medical complaint, affecting 16% of the US population with an estimated aggregated cost of $6 billion annually. Epidemiologic studies demonstrate a correlation between tobacco smoke exposure and rhinosinusitis. Although a common cause of CRS has not been defined, bacterial presence within the nasal and paranasal sinuses is assumed to be contributory. Here we demonstrate that repetitive tobacco smoke exposure induces biofilm formation in a diverse set of bacteria isolated from the sinonasal cavities of patients with CRS. Additionally, bacteria isolated from patients with tobacco smoke exposure demonstrate robust in vitro biofilm formation when challenged with tobacco smoke compared to those isolated from smoke naive patients. Lastly, bacteria from smoke exposed patients can revert to a non-biofilm phenotype when grown in the absence of tobacco smoke. These observations support the hypothesis that tobacco exposure induces sinonasal biofilm formation, thereby contributing to the conversion of a transient and medically treatable infection to a persistent and therapeutically recalcitrant condition.
dc.description.funderFlight Attendants Medical Research Institute
dc.description.funderComision Nacional de investigacion cientifica y tecnologica de Chile (CONICYT)
dc.description.funderCotutela/Codireccion 2009-2010 Pontificia Universidad Catolica de Chile
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pone.0015700
dc.identifier.issn1932-6203
dc.identifier.pubmedidMEDLINE:21253587
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0015700
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78807
dc.identifier.wosidWOS:000286511900008
dc.information.autorucMedicina;Goldstein N ;S/I;1005746
dc.issue.numero1
dc.language.isoen
dc.nota.accesoSin adjunto
dc.publisherPUBLIC LIBRARY SCIENCE
dc.revistaPLOS ONE
dc.rightsregistro bibliográfico
dc.subjectENDOSCOPIC SINUS SURGERY
dc.subjectCHRONIC RHINOSINUSITIS
dc.subjectBACTERIAL BIOFILMS
dc.subjectEPITHELIAL-CELLS
dc.subjectSTAPHYLOCOCCUS-EPIDERMIDIS
dc.subjectCOTININE LEVELS
dc.subjectAIRWAY
dc.subjectLIPOPOLYSACCHARIDE
dc.subjectACTIVATION
dc.subjectEXPRESSION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTobacco Smoke Mediated Induction of Sinonasal Microbial Biofilms
dc.typeartículo
dc.volumen6
sipa.codpersvinculados1005746
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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