Differential immune response induced by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial

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dc.catalogadorjwg
dc.contributor.authorGalvez Arriagada, Nicolás Marcelo Salvador
dc.contributor.authorPacheco Ruidiaz, Gaspar Andrés
dc.contributor.authorSchültz Lombardic, Barbara Melinka
dc.contributor.authorMelo González, Felipe Andrés
dc.contributor.authorSoto Ramírez, Jorge Andrés
dc.contributor.authorDuarte Peñaloza, Luisa Fernanda
dc.contributor.authorGonzález Carreño, Liliana Andrea
dc.contributor.authorRivera Pérez, Daniela Belén
dc.contributor.authorRíos Raggio, Mariana
dc.contributor.authorBerríos, Roslye V.
dc.contributor.authorVazquéz Hernandéz, Yaneisi
dc.contributor.authorMoreno Tapia, Daniela Paz
dc.contributor.authorVallejos Galvez, Omar Patricio
dc.contributor.authorAndrade Parra, Catalina Andrea
dc.contributor.authorHoppe Elsholz, Guillermo
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorUrzua, Marcela
dc.contributor.authorNavarrete, María S.
dc.contributor.authorRojas González, Álvaro Miguel
dc.contributor.authorFasce Pineda, Rodrigo Andrés
dc.contributor.authorFernández, Jorge
dc.contributor.authorMora, Judith
dc.contributor.authorRamírez, Eugenio
dc.contributor.authorGaete Argel, Aracelly
dc.contributor.authorAcevedo Blanco, Mónica Andrea
dc.contributor.authorValiente Echeverría, Fernando
dc.contributor.authorSoto Rifo, Ricardo
dc.contributor.authorWeiskopf, Daniela
dc.contributor.authorGrifoni, Alba
dc.contributor.authorSette, Alessandro
dc.contributor.authorZeng, Gang
dc.contributor.authorMeng, Weining
dc.contributor.authorGonzález Aramundiz, José Vicente
dc.contributor.authorGoldblatt, David
dc.contributor.authorAcuna González, Pablo Ernesto
dc.contributor.authorAbarca Villaseca, Katia
dc.contributor.authorBueno Ramírez, Susan Marcela
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.date.accessioned2025-03-17T19:56:19Z
dc.date.available2025-03-17T19:56:19Z
dc.date.issued2022
dc.description.abstractBackground: The development of vaccines to control the COVID-19 pandemic progression is a worldwide priority. CoronaVac® is an inactivated SARS-CoV-2 vaccine approved for emergency use with robust efficacy and immunogenicity data reported in trials in China, Brazil, Indonesia, Turkey, and Chile. Methods: This study is a randomized, multicenter, and controlled phase 3 trial in healthy Chilean adults aged ≥18 years. Volunteers received two doses of CoronaVac® separated by two (0-14 schedule) or four weeks (0-28 schedule). 2,302 volunteers were enrolled, 440 were part of the immunogenicity arm, and blood samples were obtained at different times. Samples from a single center are reported. Humoral immune responses were evaluated by measuring the neutralizing capacities of circulating antibodies. Cellular immune responses were assessed by ELISPOT and flow cytometry. Correlation matrixes were performed to evaluate correlations in the data measured. Results: Both schedules exhibited robust neutralizing capacities with the response induced by the 0-28 schedule being better. No differences were found in the concentration of antibodies against the virus and different variants of concern between schedules. Stimulation of PBMCs with MPs induced the secretion of IFN-γ and the expression of activation induced markers for both schedules. Correlation matrixes showed strong correlations between neutralizing antibodies and IFN-γ secretion. Conclusions: Immunization with CoronaVac® in Chilean adults promotes robust cellular and humoral immune responses. The 0-28 schedule induced a stronger humoral immune response than the 0-14 schedule.
dc.fuente.origenORCID
dc.identifier.doi10.1101/2022.08.05.22278464
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-85138654577&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102696
dc.information.autorucEscuela de Medicina; Rojas González, Álvaro Miguel; 0009-0002-6395-4162; 5994
dc.information.autorucFacultad de Ciencias Biológicas; Galvez Arriagada, Nicolás Marcelo Salvador; 0000-0003-2046-7882; 215440
dc.information.autorucFacultad de Ciencias Biológicas; Pacheco Ruidiaz, Gaspar Andrés; S/I; 1047198
dc.information.autorucFacultad de Ciencias Biológicas; Schültz Lombardic, Barbara Melinka; 0000-0002-6201-6978; 186964
dc.information.autorucFacultad de Ciencias Biológicas; Melo González, Felipe Andrés; 0000-0002-3711-2407; 149763
dc.information.autorucFacultad de Ciencias Biológicas; Soto Ramírez, Jorge Andrés; 0000-0003-0335-9759; 237269
dc.information.autorucFacultad de Ciencias Biológicas; Duarte Peñaloza, Luisa Fernanda; 0000-0003-1828-1800; 1031205
dc.information.autorucFacultad de Ciencias Biológicas; González Carreño, Liliana Andrea; S/I; 250114
dc.information.autorucFacultad de Ciencias Biológicas; Rivera Pérez, Daniela Belén; S/I; 1175592
dc.information.autorucFacultad de Ciencias Biológicas; Ríos Raggio, Mariana; S/I; 50388
dc.information.autorucFacultad de Ciencias Biológicas; Vazquéz Hernandéz, Yaneisi; S/I; 1025308
dc.information.autorucFacultad de Ciencias Biológicas; Moreno Tapia, Daniela Paz; S/I; 246324
dc.information.autorucFacultad de Ciencias Biológicas; Andrade Parra, Catalina Andrea; S/I; 234276
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan Marcela; 0000-0002-7551-8088; 113541
dc.information.autorucEscuela de Medicina; Abarca Villaseca, Katia; 0000-0003-0404-3887; 70281
dc.information.autorucFacultad de Ciencias Biológicas; Acuna González, Pablo Ernesto; S/I; 85070
dc.information.autorucEscuela de Química; González Aramundiz, José Vicente; 0000-0001-7856-9211; 17164
dc.information.autorucFacultad de Ciencias Biológicas; Vallejos Galvez Omar Patricio; S/I; 215421
dc.information.autorucEscuela de Medicina; Acevedo Blanco, Mónica Andrea; S/I; 81173
dc.information.autorucFacultad de Ciencias Biológicas; Fasce Pineda, Rodrigo Andrés; S/I; 71972
dc.language.isoen
dc.nota.accesoContenido parcial
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferential immune response induced by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial
dc.typepreprint
sipa.codpersvinculados5994
sipa.codpersvinculados215440
sipa.codpersvinculados1047198
sipa.codpersvinculados186964
sipa.codpersvinculados149763
sipa.codpersvinculados237269
sipa.codpersvinculados1031205
sipa.codpersvinculados250114
sipa.codpersvinculados1175592
sipa.codpersvinculados50388
sipa.codpersvinculados1025308
sipa.codpersvinculados246324
sipa.codpersvinculados234276
sipa.codpersvinculados90610
sipa.codpersvinculados113541
sipa.codpersvinculados70281
sipa.codpersvinculados85070
sipa.codpersvinculados17164
sipa.codpersvinculados215421
sipa.codpersvinculados81173
sipa.codpersvinculados71972
sipa.trazabilidadORCID;2025-03-03
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