<i>Pseudomonas aeruginosa</i> Community-Onset Bloodstream Infections: Characterization, Diagnostic Predictors, and Predictive Score Development-Results from the PRO-BAC Cohort

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dc.contributor.authorMartinez Perez-Crespo, Pedro Maria
dc.contributor.authorRojas, Alvaro
dc.contributor.authorFelipe Lanz-Garcia, Joaquin
dc.contributor.authorRetamar-Gentil, Pilar
dc.contributor.authorMaria Reguera-Iglesias, Jose
dc.contributor.authorLima-Rodriguez, Olalla
dc.contributor.authordel Arco Jimenez, Alfonso
dc.contributor.authorFernandez Suarez, Jonathan
dc.contributor.authorJover-Saenz, Alfredo
dc.contributor.authorGoikoetxea Aguirre, Josune
dc.contributor.authorLeon Jimenez, Eva
dc.contributor.authorLuisa Canton-Bulnes, Maria
dc.contributor.authorOrtega Lafont, Pilar
dc.contributor.authorArminanzas Castillo, Carlos
dc.contributor.authorBlanco, Juan Sevilla
dc.contributor.authorCuquet Pedragosa, Jordi
dc.contributor.authorBoix-Palop, Lucia
dc.contributor.authorBecerril Carral, Berta
dc.contributor.authorBahamonde-Carrasco, Alberto
dc.contributor.authorMarrodan Ciordia, Teresa
dc.contributor.authorNatera Kindelan, Clara
dc.contributor.authorReche Molina, Isabel Maria
dc.contributor.authorHerrero Rodriguez, Carmen
dc.contributor.authorPerez Camacho, Ines
dc.contributor.authorVinuesa Garcia, David
dc.contributor.authorGalan-Sanchez, Fatima
dc.contributor.authorSmithson Amat, Alejandro
dc.contributor.authorMerino de Lucas, Esperanza
dc.contributor.authorSanchez-Porto, Antonio
dc.contributor.authorGuzman Garcia, Marcos
dc.contributor.authorLopez-Hernandez, Inmaculada
dc.contributor.authorRodriguez-Bano, Jesus
dc.contributor.authorEduardo Lopez-Cortes, Luis
dc.date.accessioned2025-01-20T21:04:55Z
dc.date.available2025-01-20T21:04:55Z
dc.date.issued2022
dc.description.abstractCommunity-onset bloodstream infections (CO-BSI) caused by gram-negative bacilli are common and associated with significant mortality; those caused by Pseudomonas aeruginosa are associated with worse prognosis and higher rates of inadequateempirical antibiotic treatment. The aims of this study were to describe the characteristics of patients with CO-BSI caused by P. aeruginosa, to identify predictors, and to develop a predictive score for P. aeruginosa CO-BSI. Materials/methods: PROBAC is a prospective cohort including patients >14 years with BSI from 26 Spanish hospitals between October 2016 and May 2017. Patients with monomicrobial P. aeruginosa CO-BSI and monomicrobial Enterobacterales CO-BSI were included. Variables of interest were collected. Independent predictors of Pseudomonas aeruginosa CO-BSI were identified by logistic regression and a prediction score was developed. Results: A total of 78patients with P. aeruginosa CO-BSI and 2572 with Enterobacterales CO-BSI were included. Patients with P. aeruginosa had a median age of 70 years (IQR 60-79), 68.8% were male, median Charlson score was 5 (IQR 3-7), and 30-daymortality was 18.5%. Multivariate analysis identified the following predictors of CO-BSI-PA [adjusted OR (95% CI)]: male gender [1.89 (1.14-3.12)], haematological malignancy [2.45 (1.20-4.99)], obstructive uropathy [2.86 (1.13-3.02)], source of infection other than urinary tract, biliary tract or intra-abdominal [6.69 (4.10-10.92)] and healthcare-associated BSI [1.85 (1.13-3.02)]. Anindex predictive of CO-BSI-PA was developed; scores >= 3.5 showed a negative predictive value of 89% and an area under the receiver operator curve (ROC) of 0.66. Conclusions: We did not find a good predictive score of P. aeruginosa CO-BSI due to its relatively low incidence in the overall population. Our model includes variables that are easy to collect in real clinical practice and could be useful to detect patients with very low risk of P. aeruginosa CO-BSI.
dc.fuente.origenWOS
dc.identifier.doi10.3390/antibiotics11060707
dc.identifier.issn2079-6382
dc.identifier.urihttps://doi.org/10.3390/antibiotics11060707
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93270
dc.identifier.wosidWOS:000817400700001
dc.issue.numero6
dc.language.isoen
dc.revistaAntibiotics-basel
dc.rightsacceso restringido
dc.subjectPseudomonas aeruginosa
dc.subjectbacteraemia
dc.subjectbloodstream infection
dc.subjectcommunity-onset
dc.subjectepidemiology
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title<i>Pseudomonas aeruginosa</i> Community-Onset Bloodstream Infections: Characterization, Diagnostic Predictors, and Predictive Score Development-Results from the PRO-BAC Cohort
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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